• Publications
  • Influence
Synthesis of 1-aryl-1H-indazoles via palladium-catalyzed intramolecular amination of aryl halides.
The method developed is applicable for preparation of a wide scope of indazoles bearing electron-donating or electron-withdrawing substituents, among them, unprotected carboxyl, as well as various indazole heteroanalogues.
Total Synthesis of the Marine Phosphomacrolide, (-)-Enigmazole A, Exploiting Multicomponent Type I Anion Relay Chemistry (ARC) in Conjunction with a Late-Stage Petasis-Ferrier Union/Rearrangement.
An effective late-stage large-fragment union/rearrangement exploiting the Petasis-Ferrier protocol, in conjunction with multicomponent Type I Anion Relay Chemistry (ARC) to access advanced
Total Synthesis of (−)-Enigmazole A
A highly convergent, stereocontrolled total synthesis of the architecturally complex marine sponge metabolite (−)-enigmazole A has been achieved. Highlights include an unprecedented late-stage
Concise strategy to the core structure of the macrolide queenslandon.
The fully functionalized core structure of the macrolactone queenslandon was prepared using a novel strategy consisting of a glycolate aldol reaction and hydroboration of the derived enol ether 17
Synthesis of Benzomorphan Analogues by Intramolecular Buchwald–Hartwig Cyclization
A new strategy toward the important class of benzomorphans is described. The key bond formation is based on an intramolecular Buchwald–Hartwig enolate arylation reaction. Thus, alkylation of
Stereoselective synthesis of protected 1,2-diols and 1,2,3-triols by a tandem hydroboration-coupling sequence.
A new approach to complex chiral diols and polyols is described utilizing a tandem hydroboration/Suzuki cross-coupling reaction that utilizes the versatility of a glycolate-derived chiral template.