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Increased brain damage after stroke or excitotoxic seizures in melatonin‐deficient rats
TLDR
The results suggest that endogenous melatonin may play a neuroprotective role, and that melatonin deficiency might be a pathophysiological mechanism in neurodegenerative diseases. Expand
Photothrombotic brain infarction results in seizure activity in aging Fischer 344 and Sprague Dawley rats
TLDR
The primary finding of this study was that epileptic seizures were recorded in post-mature rats 2 months after lesioning the frontoparietal cortex with large photothrombotic infarcts that extended to the cortical-subcortical interface. Expand
Suramin reduces infarct volume in a model of focal brain ischemia in rats
TLDR
Interference with the ATP excitatory system could provide neuroprotection from brain ischemia, and findings indicate that suramin at 100 mg/kg is an effective pre-treatment neuroprotective agent. Expand
Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter.
TLDR
The structure and the preclinical validation profile of a novel phospholipid encapsulated sirolimus nanocarrier, used as a coating in two formulations: a coronary stent-plus-balloon system and a stand-alone balloon catheter are described. Expand
Ganglioside GM1 and its semisynthetic lysogangliosides reduce glutamate neurotoxicity by a novel mechanism.
TLDR
In the brain interneuronal communications occur at synapses, where nerve impulses reaching the presynaptic terminal release a transmitter which is stored in synaptic vesicles preferentially located in the nerve terminal and diffuses into accessible intraneuronal metabolic compartments of the receiving neuron. Expand
Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia.
TLDR
It would appear that a better understanding of those factors that contribute to the astrocytic response in the aged rat may be of particular benefit in designing therapeutic strategies aimed at reducing the pathologic consequences of cerebral infarction in elderly humans. Expand
Stroke Onset Time Using Sodium MRI in Rat Focal Cerebral Ischemia
TLDR
Results of sodium MRI show that the region of maximum [Na+]br increase corresponds to the ischemic region, and, therefore, onset time can be estimated, suggesting this method can be used as a ticking clock to estimate time elapsed after vascular occlusion. Expand
Silica-gold nanoparticles for atheroprotective management of plaques: results of the NANOM-FIM trial.
TLDR
A nano-intervention with delivery of silica-gold NP in a bioengineered on-artery patch is associated with significant regression of coronary atherosclerosis and the analysis of the event free survival of the ongoing clinical follow-up shows the significantly lower risk of cardiovascular death in the Nano group. Expand
Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72.
TLDR
The results suggest that in response to focal brain injury, some cells die through an apoptotic process that might involve an accumulation of p53. Expand
Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion
TLDR
The demonstration that in the area penumbra the neurons degeneration and the persistent translocation of PKC can be inhibited by a pretreatment with dizocilpine indicates that the dynamics of the progression of the neuronal degeneration are maintained by glutamate accumulating in the extraneuronal fluids. Expand
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