A. Khandwala

Publications73
h-index18
Citations1,000
Highly Influential Citations13
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A double blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS
Objective:The aim of this study was to investigate the safety and effectiveness of orally administered SP-303 in patients with AIDS and diarrhea.Methods:This is a multicenter, phase II, randomized,… Expand
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Preferential induction of aryl hydroxylase activity in rat liver nuclear envelope by 3-methylcholanthrene.
Abstract The specific activity of aryl hydroxylase associated with the nuclear envelope from rat hepatocytes is increased 17-fold by the intraperitoneal administration of 3-methylcholanthrene. This… Expand
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REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile.
REV 5901 [alpha-pentyl-3-(2-quinolinylmethoxy)-benzene-methanol] has been shown to be a competitive antagonist of peptidoleukotrienes. In vitro it has a Ki value of 0.7 microM vs. [3H]leukotriene D4… Expand
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Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.
A series of new substituted arylmethyl phenyl ethers has been prepared. These compounds were tested as inhibitors of 5-lipoxygenase (5-LO) in rat neutrophils, in vitro antagonists of… Expand
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Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers.
Five percent Amlexanox oral paste is a novel treatment for aphthous ulcers. In 3 controlled clinical studies that evaluated 1,124 immunocompetent patients with mild to moderate aphthous ulcers, 5%… Expand
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1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents.
A series of new 1,4-dihydro-1,2,4-triazolo[4,3-]quinoxaline-1,4-diones has been prepared. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat… Expand
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Inhibition of the effects of thrombin on guinea pig platelets by the diacylglycerol lipase inhibitor RHC 80267.
Phospholipase C (PLC) and diacylglycerol lipase (DGL) activities were found in guinea pig platelet microsome preparations. No phospholipase A2 (PLA2) activity was detected. RHC 80267 (1,6-di… Expand
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Loss of IgE receptors and shedding of a protease during purification of mast cells.
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Angiotensin-Converting Enzyme Inhibitors: New Orally Active 1,4-Thiazepine- 2,5-diones, 1,4-Thiazine-2,5-diones, and 1,4-Benzothiazepine-2,5- diones Possessing Antihypertensive Activity.
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Antiallergic activity of tiaramide (RHC 2592-A).
Tiaramide (RHC 2592-A) is an analgesic agent with antiallergic activity in vivo. We have investigated the antianaphylactic properties of tiaramide and its metabolites in three in vitro models of… Expand
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