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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Colonic bacterial composition in Parkinson's disease
- A. Keshavarzian, S. Green, K. Shannon
- Biology, MedicineMovement disorders : official journal of the…
- 1 September 2015
It is shown that Parkinson's disease (PD) patients have alpha‐synuclein aggregation in their colon with evidence of colonic inflammation, and dysbiosis might be the mechanism of neuroinflammation that leads to α‐Syn misfolding and PD pathology.
Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease
The data show that PD subjects exhibit significantly greater intestinal permeability (gut leakiness) than controls and this intestinal hyperpermeability significantly correlated with increased intestinal mucosa staining for E. coli bacteria, nitrotyrosine, and alpha-synuclein as well as serum LBP levels in PD subjects.
A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects
The composition of the HIV microbiome was significantly different than that of controls; it was less diverse in the right colon and terminal ileum, and was characterized by loss of bacterial taxa that are typically considered commensals in HIV samples.
Colonic microbiome is altered in alcoholism.
- E. Mutlu, P. Gillevet, A. Keshavarzian
- MedicineAmerican journal of physiology. Gastrointestinal…
- 1 May 2012
It is shown that the colonic mucosa-associated bacterial microbiome is altered in a subset of alcoholics, and this alteration is seen even after an extended period of sobriety, and correlates with endotoxemia in a subgroup ofcoholics.
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
Given that the majority of the biological and human health variables remained stable, or returned to baseline, after a 340-day space mission, these data suggest that human health can be mostly sustained over this duration of spaceflight.
Intestinal Permeation and Gastrointestinal Disease
- M. Demeo, E. Mutlu, A. Keshavarzian, M. Tobin
- MedicineJournal of clinical gastroenterology
- 1 April 2002
An overview of the evidence for the role of gut barrier dysfunction in disorders such as Crohn's disease, celiac disease, food allergy, acute pancreatitis, non-alcoholic fatty liver disease, and alcoholic liver disease is provided, together with critical insight into the implications of this evidence as a primary disease mechanism.
Progression of intestinal permeability changes and alpha‐synuclein expression in a mouse model of Parkinson's disease
LPS, an endotoxin used to model PD, causes sequential increases in α‐syn immunoreactivity, intestinal permeability, and pathological α‐ syn accumulation in the colon in a manner similar to that observed in patients with PD.