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Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved.
Biotransformation of cerivastatin, a new cholesterol-lowering drug, by human liver microsomes was investigated using the 14C-labeled drug. Metabolite profiles were established by HPLC and structuresExpand
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Biotransformation of cerivastatin in mice, rats, and dogs in vivo.
Biotransformation of cerivastatin was investigated in mice, rats, and dogs in vivo using the 14C-labeled drug. Marked species differences exist, both in pathways and extent of cerivastatinExpand
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Costing Practices in Healthcare
SYNOPSIS: The rising cost of healthcare is a globally pressing concern. This makes detailed attention to the way in which costing is carried out of central importance. This article offers a frameworkExpand
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Exploring the Relation Between Creativity and Rules: The Case of the Performing Arts
This research uses a cultural–historical psychology perspective and examples from performing arts to elucidate the relation between creativity and rules. The research assumes that the concepts ofExpand
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Biotransformation of nitrendipine in rat, dog, and mouse.
14C-Labelled Nitrendipine (Bay e 5009; Baypress, Bayotensin; CAS 39562-70-4) was administered by the oral and intraduodenal route to rats, dogs, and mice (oral dosing only) to elucidate theExpand
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Costing in the National Health Service : from reporting to managing
• Set out more clearly the underlying philosophy of cost analysis and management in official DH documents. • Develop training for NHS staff in the roles and potentials of appropriately constructedExpand
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SYNTHESIS OF SPACERED CYCLOPROPYL NUCLEOSIDE ANALOGUES AS POTENTIAL ANTIVIRAL AGENTS
Abstract Novel spacered cyclopropane nucleoside analogues possessing both a hydroxyethyl group and an additional methylene spacer between the base and the ring were synthesized starting fromExpand
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International Approaches to clinical costing
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Synthesis and HPLC-Analysis of N-(2-Phenyl-cyclopropyl)-Substituted Chain Elongated Nucleoside Analogues
A novel class of nucleoside analogues containing adenine, uracil, thymine and 5-fluorouracil as the heterocyclic moieties have been prepared from 2-phenylcyclopropane carboxylic acid. These compoundsExpand
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