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Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70S6K Pathways*
Thyroid hormones affect cardiac growth and phenotype; however, the mechanisms by which the hormones induce cardiomyocyte hypertrophy remain uncharacterized. Tri-iodo-l-thyronine (T3) treatment ofExpand
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Thyroid hormone regulation of phospholamban phosphorylation in the rat heart.
Thyroid hormone exerts predictable effects on the contractile performance of the heart in part by regulating the transcription of genes encoding specific calcium transporter proteins. In a rat modelExpand
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Degradation of Tau by Lysosomal Enzyme Cathepsin D: Implication for Alzheimer Neurofibrillary Degeneration
Abstract: The degradation of different isoforms of human recombinant tau (R‐tau; T39, T40, and T44) and fetal tau (F‐tau) by cathepsin D (CD) was investigated. Gel electrophoresis and Coomassie BlueExpand
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Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat.
In a rat model of acute myocardial infarction (MI) produced by coronary artery ligation, thyroid hormone metabolism was altered with significant reductions (54%) in serum triiodo-L-thyronine (T(3)),Expand
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Macrophage migration inhibitory factor provides cardioprotection during ischemia/reperfusion by reducing oxidative stress.
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that exhibits an intrinsic thiol protein oxidoreductase activity and proinflammatory activities. In the present study toExpand
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Protein content of various regions of rat brain and adult and aging human brain
The protein content of 14 rat brain regions and 44 human brain regions was assayed. With the human tissue we compared brain areas from adult with those from aged subjects. In each case tissue wasExpand
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Regulation of rat cardiac Kv1.5 gene expression by thyroid hormone is rapid and chamber specific.
Thyroid hormone affects the contractile and electrophysiological properties of the cardiac myocyte that result in part from changes in the expression of thyroid hormone-responsive cardiac genes,Expand
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Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart.
OBJECTIVES The objective of the present study was to determine whether improved contractility after left ventricular assist device (LVAD) support reflects altered myocyte calcium cycling and changesExpand
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Role of USF1 phosphorylation on cardiac α-myosin heavy chain promoter activity
Contractile activity of the cardiac myocyte is required for maintaining cell mass and phenotype, including expression of the cardiac-specific α-myosin heavy chain (α-MHC) gene. An E-box hemodynamic...
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THE EFFECT OF LIVE WEIGHT ON THE CARCASS TRAITS AND THE CHEMICAL COMPOSITION OF MEAT OF PANNON WHITE RABBITS BETWEEN 2.2 AND 3.5 KGS.
For 267 Pannon White growing rabbits of both sexes slaughtered at a body weight of 2.2-2.4, 2.4-2.6, 2.6-2.8, 2.8-3.0, 3.0-3.2, 3.2-3.4 and 3.4-3.5 kg, the average dressing percentage was 59.5, 60.7,Expand
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