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Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70S6K Pathways*
Thyroid hormones affect cardiac growth and phenotype; however, the mechanisms by which the hormones induce cardiomyocyte hypertrophy remain uncharacterized. Tri-iodo-l-thyronine (T3) treatment of… Expand
Thyroid hormone regulation of phospholamban phosphorylation in the rat heart.
Thyroid hormone exerts predictable effects on the contractile performance of the heart in part by regulating the transcription of genes encoding specific calcium transporter proteins. In a rat model… Expand
Degradation of Tau by Lysosomal Enzyme Cathepsin D: Implication for Alzheimer Neurofibrillary Degeneration
Abstract: The degradation of different isoforms of human recombinant tau (R‐tau; T39, T40, and T44) and fetal tau (F‐tau) by cathepsin D (CD) was investigated. Gel electrophoresis and Coomassie Blue… Expand
Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat.
- K. Ojamaa, A. Kenessey, R. Shenoy, I. Klein
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 1 December 2000
In a rat model of acute myocardial infarction (MI) produced by coronary artery ligation, thyroid hormone metabolism was altered with significant reductions (54%) in serum triiodo-L-thyronine (T(3)),… Expand
Macrophage migration inhibitory factor provides cardioprotection during ischemia/reperfusion by reducing oxidative stress.
- Kiyokazu Koga, A. Kenessey, S. Powell, C. Sison, E. Miller, K. Ojamaa
- Chemistry, Medicine
- Antioxidants & redox signaling
- 8 March 2011
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that exhibits an intrinsic thiol protein oxidoreductase activity and proinflammatory activities. In the present study to… Expand
Protein content of various regions of rat brain and adult and aging human brain
The protein content of 14 rat brain regions and 44 human brain regions was assayed. With the human tissue we compared brain areas from adult with those from aged subjects. In each case tissue was… Expand
Regulation of rat cardiac Kv1.5 gene expression by thyroid hormone is rapid and chamber specific.
Thyroid hormone affects the contractile and electrophysiological properties of the cardiac myocyte that result in part from changes in the expression of thyroid hormone-responsive cardiac genes,… Expand
Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart.
- Khuram W. Chaudhary, E. Rossman, +8 authors K. Margulies
- Journal of the American College of Cardiology
- 18 August 2004
OBJECTIVES The objective of the present study was to determine whether improved contractility after left ventricular assist device (LVAD) support reflects altered myocyte calcium cycling and changes… Expand
Role of USF1 phosphorylation on cardiac α-myosin heavy chain promoter activity
Contractile activity of the cardiac myocyte is required for maintaining cell mass and phenotype, including expression of the cardiac-specific α-myosin heavy chain (α-MHC) gene. An E-box hemodynamic...
THE EFFECT OF LIVE WEIGHT ON THE CARCASS TRAITS AND THE CHEMICAL COMPOSITION OF MEAT OF PANNON WHITE RABBITS BETWEEN 2.2 AND 3.5 KGS.
For 267 Pannon White growing rabbits of both sexes slaughtered at a body weight of 2.2-2.4, 2.4-2.6, 2.6-2.8, 2.8-3.0, 3.0-3.2, 3.2-3.4 and 3.4-3.5 kg, the average dressing percentage was 59.5, 60.7,… Expand