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A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.
The role of DNA methylation and of the maintenance DNA methyltransferase Dnmt1 in the epigenetic regulation of developmental stage- and cell lineage-specific gene expression in vivo is uncertain.Expand
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The Global Circulation of Seasonal Influenza A (H3N2) Viruses
Antigenic and genetic analysis of the hemagglutinin of ∼13,000 human influenza A (H3N2) viruses from six continents during 2002–2007 revealed that there was continuous circulation in east andExpand
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Global circulation patterns of seasonal influenza viruses vary with antigenic drift
We show that the global circulation patterns of influenza A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/ H3N2 viruses, on the basis of analyses of 9,604 haemagglutinin sequences of human seasonal influenza viruses. Expand
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Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation
ABSTRACT The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. AlthoughExpand
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Th1 and Th2 subsets: paradigms lost?
  • A. Kelso
  • Biology, Medicine
  • Immunology today
  • 1 August 1995
The T helper 1 (Th1)/Th2 model has provided a valuable framework to investigate and explain many immune reactions and now pervades current thinking on the regulatory role of T cells. However,Expand
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Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses.
Annual influenza epidemics in humans affect 5-15% of the population, causing an estimated half million deaths worldwide per year [Stohr K. Influenza-WHO cares. Lancet Infectious DiseasesExpand
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Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa.
The neuraminidase inhibitors (NAIs) are an effective class of antiviral drugs for the treatment of influenza A and B infections. Until recently, only a low prevalence of NAI resistance (<1%) had beenExpand
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Cytokines: Principles and prospects
  • A. Kelso
  • Biology, Medicine
  • Immunology and cell biology
  • 1 July 1998
Cytokines participate in the induction and effector phases of all immune and inflammatory responses. They are therefore obvious tools and targets for strategies designed to promote, inhibit orExpand
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Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
Oseltamivir is relied upon worldwide as the drug of choice for the treatment of human influenza infection. Surveillance for oseltamivir resistance is routinely performed to ensure the ongoingExpand
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Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice
Influenza virus infection activates cytolytic T lymphocytes (CTL) that contribute to viral clearance by releasing perforin and granzymes from cytoplasmic granules. Virus-specific, perforin-dependentExpand
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