• Publications
  • Influence
Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
  • A. Kelley
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 31 January 2004
The nucleus accumbens is a brain region that participates in the control of behaviors related to natural reinforcers, such as ingestion, sexual behavior, incentive and instrumental learning, and thatExpand
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The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Addictive drugs act on brain reward systems, although the brain evolved to respond not to drugs but to natural rewards, such as food and sex. Appropriate responses to natural rewards wereExpand
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Memory and Addiction Shared Neural Circuitry and Molecular Mechanisms
  • A. Kelley
  • Psychology, Medicine
  • Neuron
  • 30 September 2004
An important conceptual advance in the past decade has been the understanding that the process of drug addiction shares striking commonalities with neural plasticity associated with natural rewardExpand
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A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward
We elaborate herein a novel theory of basal ganglia function that accounts for why palatable, energy‐dense foods retain high incentive value even when immediate physiological energy requirements haveExpand
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Opioid modulation of taste hedonics within the ventral striatum
There is a long-standing interest in the role of endogenous opioid peptides in feeding behavior and, in particular, in the modulation of food reward and palatability. Since drugs such as heroin,Expand
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Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
Work over the past decade has supported the idea that discrete aspects of appetitive motivation are differentially mediated by separate but interacting neurochemical systems within the nucleusExpand
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PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories
How long-term memories are stored is a fundamental question in neuroscience. The first molecular mechanism for long-term memory storage in the brain was recently identified as the persistent actionExpand
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GABA in the Nucleus Accumbens Shell Participates in the Central Regulation of Feeding Behavior
We have demonstrated previously that injections of 6,7-dinitroquinoxaline-2,3-dione into the nucleus accumbens shell (AcbSh) elicits pronounced feeding in satiated rats. This glutamate antagonistExpand
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Overlapping distributions of orexin/hypocretin‐ and dopamine‐β‐hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress
A double‐label immunohistochemical study was carried out to investigate overlap between dopamine‐β‐hydroxylase (DβH) ‐immunopositive projections and the projections of hypothalamic neurons containingExpand
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Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens.
The present study was designed to further investigate the nature of feeding induced by opioid stimulation of the nucleus accumbens through an examination of the effects of intra-accumbens (ACB)Expand
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