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Mdm2 promotes the rapid degradation of p53
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by mutations that… Expand
c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53*
- Ronit Vogt Sionov, E. Moallem, +5 authors Y. Haupt
- Biology, Medicine
- The Journal of Biological Chemistry
- 26 March 1999
Upon exposure to stress signals, the p53 tumor suppressor protein is stabilized and induces growth suppression. p53 activities are efficiently inhibited by the Mdm2 oncoprotein through an… Expand
p53 mediated apoptosis in HeLa cells: transcription dependent and independent mechanisms.
The most frequent target for genetic alterations in human cancers is the p53 tumor suppressor gene. Mutations in p53 abrogate its ability to inhibit cell growth and to suppress tumor progression. The… Expand