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Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro.
The mechanisms of TSH-induced growth stimulation of thyrocytes in vivo have yet to be elucidated. We examined the antiapoptotic effect of TSH toward Fas antigen-mediated apoptosis of thyrocytes. FasExpand
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Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast‐like cells
This study was undertaken to investigate the immunomodulatory effect of clarithromycin against synovial fibroblast‐like cells (synoviocytes). Synovial tissue obtained from rheumatoid arthritis (RA)Expand
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Osteoprotegerin (OPG) acts as an endogenous decoy receptor in tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐mediated apoptosis of fibroblast‐like synovial cells
We examined the role of osteoprotegerin (OPG) on tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐induced apoptosis in rheumatoid fibroblast‐like synovial cells (FLS). OPG proteinExpand
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A novel mutation (T61I) in the gene encoding tumour necrosis factor receptor superfamily 1A (TNFRSF1A) in a Japanese patient with tumour necrosis factor receptor-associated periodic syndrome (TRAPS)
OBJECTIVE To identify potential mutations in the tumour necrosis factor receptor superfamily 1A gene (TNFRSF1A) in a Japanese female patient with recurrent fever complicated by systemic lupusExpand
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Inhibition of Caspase Cascade by HTLV-I Tax Through Induction of NF-κB Nuclear Translocation
NF-κB is required for prevention of apoptosis. We examined the importance of human T-cell leukemia virus–I (HTLV-I) Tax protein to stimulate NF-κB nuclear translocation, thus preventing apoptosis.Expand
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Inhibition of caspase cascade by HTLV-I tax through induction of NF-kappaB nuclear translocation.
NF-kappaB is required for prevention of apoptosis. We examined the importance of human T-cell leukemia virus-I (HTLV-I) Tax protein to stimulate NF-kappaB nuclear translocation, thus preventingExpand
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A novel role for interleukin-18 in human natural killer cell death: high serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases.
OBJECTIVE Patients with systemic autoimmune diseases have been reported to have reduced numbers of peripheral blood natural killer (NK) cells compared with healthy subjects. The ability of selectedExpand
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Relationship between Sjögren's syndrome and human T-lymphotropic virus type I infection: follow-up study of 83 patients.
We have previously demonstrated a high prevalence of Sjögren's syndrome (SS) in patients with human T-lymphotropic virus type I-associated myelopathy (HAM) in Nagasaki prefecture. The presentExpand
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PAX6 expression in the developing human eye
AIMS To investigate the changes in PAX6 expression in the developing human eye. METHODS Six developing human eyes from 6 to 22 weeks’ gestation were evaluated. Frozen sections wereExpand
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Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells.
Nitric oxide (NO) is a multifunctional messenger molecule generated from L-arginine by a family of enzymes, including nitric oxide synthase (NOS). This study was performed to examine whether NOExpand
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