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Radiobiologic principles in radionuclide therapy.
The special features that characterize the biologic effects consequent to the traversal of charged particles through mammalian cells are explored with respect to DNA lesions and cellular responses. Expand
Therapeutic radionuclides: biophysical and radiobiologic principles.
  • A. Kassis
  • Medicine
  • Seminars in nuclear medicine
  • 1 September 2008
This review explores the special features that distinguish the biologic effects consequent to the traversal of charged particles through mammalian cells and highlights what has been learned when these radionuclides and radiotargeting pharmaceuticals are used to treat cancers. Expand
Radiotoxicity of 125I in mammalian cells.
It is indicated that a high dose deposited within the cytoplasm contributes minimally to radiation-induced cell death and that radiotoxicity depends not upon the specific activity of IUdR but upon the absolute amount of 125I that is associated with nuclear DNA. Expand
Kinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes.
The kinetics of uptake, retention, and radiotoxicity of 125IUdR have been studied in proliferating mammalian cells in culture and the strong cytocidal effects of the decay of 125I correlate with localized irradiation of the DNA by the low energy Auger electrons. Expand
The Amazing World of Auger Electrons
  • A. Kassis
  • Physics, Medicine
  • International journal of radiation biology
  • 1 January 2004
An overview of the exciting findings reported in this field is presented and the unique opportunities given to the fortunate few who have, mostly through serendipity, been working within the fascinating world of Auger electron emitters are outlined. Expand
Radiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: a comparison with 5-[125I]iodo-2'-deoxyuridine.
The results indicate that there are no saturation effects in the decay of 125IUdR in the DNA of V79 cells and that each of the two steps involved in the 125I decay is equally effective in causing biological damage. Expand
Effect of distance between decaying 125I and DNA on Auger-electron induced double-strand break yield
Results suggest that at a critical distance between the 125I atom and the DNA helix, DSB production switches from an ’all’ direct to an ‘ all’ indirect mechanism, the latter situation being comparable to the decay of 125I free in solution. Expand
Comparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125.
To elucidate the kinetics of the induction of DNA strand breaks by low-energy Auger electron emitters, the yields of DNA breaks in supercoiled pUC19 DNA after the decay of 125I in proximity to DNA after minor-groove binding and at a distance from DNA are compared. Expand
Radiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy.
It is learned that radiobiologic responses to Auger-electron emission are particularly sensitive to the site of decay, not only within the cell but also in the nucleus within the fine structure of chromatin. Expand
Molecular and cellular radiobiological effects of Auger emitting radionuclides.
  • A. Kassis
  • Chemistry, Medicine
  • Radiation protection dosimetry
  • 1 February 2011
The ability of track structural simulations as primary tools in modelling DNA damage and cellular survival at the molecular level would be greatly enhanced when these contributions to radiobiological effects of Auger electron-emitting radionuclides are factored in. Expand