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The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.
TLDR
Results imply that interaction between Peptide-25/I-Ab and TCR may primarily influence determination of the fate of naive CD4+ T cells in their differentiation towards the Th1 subset. Expand
Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis
TLDR
T reg cells recognizing Mtb-derived antigens specifically and potently restrict protective immune responses during tuberculosis, and this delay likely prolongs the initial phase of bacterial expansion and explains the higher bacterial burden observed in these mice. Expand
Excessive function of peripheral blood neutrophils from patients with Behçet's disease and from HLA-B51 transgenic mice.
TLDR
The HLA-B51 molecule itself may be responsible, at least in part, for neutrophil hyperfunction in Behçet's disease. Expand
Mapping of V beta 11+ helper T cell epitopes on mycobacterial antigen in mouse primed with Mycobacterium tuberculosis.
TLDR
It is concluded that MPT59 and peptide-25 (amino acids 240-254) are not superantigens and require antigen processing in order to stimulate V beta 11+ Th1 cells. Expand
Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.
TLDR
Results indicate that TLR7 is a receptor for 8-SGuo and plays an essential role in the AID and Blimp-1 expression; however it is not enough to complete mu to gamma1 CSR in CD38-activated B cells. Expand
Presentation of human minor histocompatibility antigens by HLA-B35 and HLA-B38 molecules.
TLDR
Data demonstrated that the five amino acids substitutions on the alpha 1 domain between HLA-B35 and -Bw53, which are associated with Bw4/Bw6 epitopes, play a critical role in the relationship of hmHA-1 to HLA -B35 molecules. Expand
One-way occurrence of graft-versus-host disease in bone marrow chimaeras between congenic MRL mice.
TLDR
The data suggest that injected T cell precursors of MRL/l mice become mature through the host (MRL/n mice) thymus and appear in the periphery as functioning T cells, resulting in the appearance of GVHD. Expand
HLA-B51 transgenic mice as recipients for production of polymorphic HLA-A, B-specific antibodies
TLDR
The present study attempted to produce polymorphic antibodies for HLA-A, B, and C antigens in H LA-B51 TGM using HLA class I TGM to demonstrate the ability of these mAbs to recognize xenogeneic determinants of HLA antIGens. Expand
The immunogenic peptide for Th1 development.
TLDR
Peptide-25 has a potent adjuvant activity in both humoral and cell-mediated immune responses that is mediated by Th1 cells, and is proposed to be designated as "Th1-inducing peptide". Expand
The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.
TLDR
Investigation of TLR4- or RP105-dependent MZ B cell responses by utilizing agonistic monoclonal antibodies to each receptor induced robust IgM-secreting plasma cell generation as lipid A moiety of LPS. Expand
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