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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
Runx3/Pebp2alphaC null mouse gastric mucosa exhibits hyperplasias due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-inhibitory andExpand
Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice
Altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk, as seen in the normal colonic mucosa of humans with LOI. Expand
Three DNA Methylation Epigenotypes in Human Colorectal Cancer
Three methylation epigenotypes exist in colorectal cancer, and suitable classification markers have been developed, and intermediate-methylation epigenotype with KRAS-mutation(+) correlated with worse prognosis. Expand
High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
It was indicated that H. pylori infection potently induces methylation of CGIs to various degrees, and methylation levels of specific CGIs seemed to reflect gastric cancer risk in H.pylori–negative individuals. Expand
Identification of genes preferentially methylated in hepatitis C virus‐related hepatocellular carcinoma
DNA methylation might play an important role in HCV‐related HCC by silencing cancer‐related pathway inhibitors, and might perhaps be useful as a prognostic marker. Expand
RUNX3 Suppresses Gastric Epithelial Cell Growth by Inducing p21WAF1/Cip1 Expression in Cooperation with Transforming Growth Factor β-Activated SMAD
It is shown that RUNX3 is required for the TGF-β-dependent induction of p21 expression in stomach epithelial cells, and the results suggest that at least part of the tumor suppressor activity of RUNx3 is associated with its ability to induce p 21 expression. Expand
CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas.
The results showed that neuroblastomas with CIMP have a poor prognosis and suggested induction of silencing of important genes as an underlying mechanism. Expand
Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes.
DNA methylation profiling classified gastric cancer into 3 epigenotypes, and EBV(+) gastric cancers showed distinct methylation patterns likely attributable to EBV infection. Expand
Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes
This work epigenotyped colorectal cancer by a comprehensive approach using the two‐way unsupervised hierarchical clustering method using highly quantitative methylation data by a single detection method, MALDI‐TOF mass spectrometry, on novel regions selected genome‐widely through methylated DNA immunoprecipitation on array analysis. Expand
Lysyl Oxidase Is a Tumor Suppressor Gene Inactivated by Methylation and Loss of Heterozygosity in Human Gastric Cancers
Data showed that LOX is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in gastric cancers, and possibly also in other cancers. Expand