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Molecular epidemiology of HIV.
TLDR
The phylogenic analysis of the nucleotide sequences of the env gene has enabled classification of HIV-1 into three groups, which are A-H, A-K and C, which suggest that subtype C strains would dominate the HIV pandemic in the coming years.
Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs
TLDR
The plasma virome of persons heavily exposed to bloodborne infections through long-term injection drug use is explored to explore whether next-generation metagenomic sequencing would reveal additional viruses.
Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver.
TLDR
Quantitative single-cell RNA measurements can be used to estimate the abundance of HCV vRNA per infected human hepatocyte and are consistent with cell-cell propagation of infection in the absence of clustered IFITM3, which shows that expression of antiviral molecules is scattered among hepatocytes.
Inferring Viral Dynamics in Chronically HCV Infected Patients from the Spatial Distribution of Infected Hepatocytes
TLDR
This study presents methods to analyze the spatial distribution of infected hepatocytes obtained by single cell laser capture microdissection from liver biopsy samples of patients chronically infected with HCV, and represents a novel approach to make inferences about infection dynamics in solid tissues from static spatial data.
The frequency of HIV-I drug resistance mutations among treatment-naïve individuals at a tertiary care centre in south India
TLDR
Resistance predictor mutations and polymorphisms in HIV-1 pol gene among treatment-naïve individuals were similar when compared with previous data.
Drug resistant mutations detected by genotypic drug resistance testing in patients failing therapy in clade C HIV-1 infected individuals from India.
TLDR
Resistance testing to check the prevalence of drug resistance mutations that arise following failure of the first line regimen to establish guidelines for second line regimens in India is a must.
Usefulness of Alternate Prognostic Serum and Plasma Markers for Antiretroviral Therapy for Human Immunodeficiency Virus Type 1 Infection
TLDR
Among the three plasma markers the authors tested, plasma albumin and, to some extent, DHEAS show promise as prognostic markers in monitoring HIV infection.
High rates of regimen change due to drug toxicity among a cohort of South Indian adults with HIV infection initiated on generic, first-line antiretroviral treatment.
TLDR
The ART regimens used in this study were effective in decreasing disease progression and death, however, they were associated with high rates of drug toxicities, particularly those attributable to thymidine analogue NRTI.
Comparison of Microcapillary Cytometry Technology and Flow Cytometry for CD4+ and CD8+ T-Cell Estimation
TLDR
An alternative technology for the estimation of T cells based on a microcapillary technique (Guava Technologies, Hayward, CA) was compared to FACSCount, establishing equable performance between the two technologies.
Genotypic resistance profile of HIV-1 protease gene: a preliminary report from Vellore, south India.
TLDR
The use of resistance testing to monitor individuals on therapy and also before initiation of therapy, gathering more sequence information for a data bank of Indian strains is suggested.
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