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Splenocytes Can Replace Chimeric Cells and Maintain Allograft Tolerance
Background. The induction of donor-specific tolerance (DST) has recently attracted widespread attention as a new approach to facilitate engraftment without using immunosuppressants. One way in whichExpand
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Active Role of Chimerism in Transplantation Tolerance Induced by Antilymphocyte Serum, Sirolimus, and Bone–Marrow-Cell Infusion
Background. A regimen consisting of antilymphocyte serum (ALS), sirolimus, and donor bone–marrow-cell (BMC) infusion induces indefinite skin allograft survival across fully mismatched mouse strainExpand
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Chimeric Donor Cells Play an Active Role in Both Induction and Maintenance Phases of Transplantation Tolerance Induced by Mixed Chimerism1
Donor hemopoietic cell engraftment is considered to be an indicator of allograft tolerance. We depleted chimerism with cells specifically presensitized to the bone marrow donor to investigate itsExpand
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Partially MHC-matched donor CD8+ T cells are indispensable for switching to splenocytic chimerism.
BACKGROUND We have shown that partially major histocompatibility complex (MHC)-matched splenocytes can replace bone marrow (BM) and maintain skin grafts by establishing splenocytic chimeras. Our aimExpand
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SV40 Infection Associated With Rituximab Treatment After Kidney Transplantation in Nonhuman Primates
Background. A regimen consisting of polyclonal anti-T-cell antibody, sirolimus (SRL), and donor bone marrow (DBM) infusion induces robust transplantation tolerance to skin allografts in mice. WeExpand
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Chimeric acceleration by donor CD4+CD25+T-reg depleted fraction in splenocyte transplantation.
BACKGROUND We have established a splenocytic chimera model that can induce donor-specific tolerance and reconstitute the recipient immune system by donor splenocytes. AIM To accelerate suchExpand
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Milk fat globule epidermal growth factor–8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms
1. 1. Jinushi, 2. et al . 2009. J. Exp. Med. doi: 10.1084/jem.20082614 [OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
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Vaccination using class-I restricted epitope peptide derived from vascular endothelial growth factor receptor 2 induces specific cellular immune responses in patients with advanced cancer: a phase I
AACR Centennial Conference: Translational Cancer Medicine-- July 20-23, 2008; Monterey, CA B2 Purpose: Angiogenesis has been shown to be a critical mechanism for tumor progression. MultipleExpand