• Publications
  • Influence
Oxidation events and skin aging
The rate of skin aging, or that of tissue in general, is determined by a variable predominance of tissue degeneration over tissue regeneration. This review discusses the role of oxidative events ofExpand
The relation between constitutional skin color and photosensitivity estimated from UV-induced erythema and pigmentation dose-response curves.
In 54 healthy volunteers we assessed predictors of sensitivity to ultraviolet (UV) light, including Fitzpatrick's sun reactive skin types and constitutional skin color, and compared these with oneExpand
Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods
Background  The carriers of loss‐of‐function mutations in the filaggrin gene (FLG) have reduced levels of natural moisturizing factor (NMF) in the stratum corneum. The concentration of NMF componentsExpand
Prolonged Increase of cis‐Urocanic Acid Levels in Human Skin and Urine after Single Total‐body Ultraviolet Exposures
Cis-urocanic acid (cis-UCA), a mediator of immunosuppression, is formed from trans-UCA upon UV-exposure of the skin. This study describes a liquid chromatographic method for the simultaneousExpand
The spectral stability of several sunscreening agents on stratum corneum sheets
Film layers of seventeen commercially available sunscreen products and sixteen active ingredients on stratum corneum sheets were spectrophotometrically monitored before and after simulated solarExpand
Determination of catechol O-methyltransferase activity in relation to melanin metabolism using high-performance liquid chromatography with fluorimetric detection.
A new sensitive method for the determination of catechol O-methyltransferase activity has been developed. The method is based on the O-methylation of the indolic intermediates of melanin metabolism.Expand
Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection.
Urocanic acid (UCA) is produced by the enzyme histidase and accumulates in the stratum corneum of the epidermis. In this study, we investigated the photoprotective role of endogenous UCA in theExpand
In vitro tissue-digesting properties of krill enzymes compared with fibrinolysin/DNAse, papain and placebo.
Wound debridement, the removal of necrotic tissue, can be achieved with proteolytic enzymes. Recently, a new multi-enzyme preparation, krill enzyme, isolated from Antarctic shrimp-like organismsExpand
Photoisomerization spectrum of urocanic acid in human skin and in vitro: effects of simulated solar and artificial ultraviolet radiation
Summary Ultraviolet (UV) irradiation of trans‐urocanic acid (UCA), a major UV absorbing component of the epidermis, leads to the formation of cis‐UCA, which mediates immunosuppressive effects. InExpand
Oxidative breakdown and conversion of urocanic acid isomers by hydroxyl radical generating systems.
cis-Urocanic acid (cis-UCA), formed from trans-urocanic acid (trans-UCA) by photoisomerization, has been shown to mimic suppressive effects of UV on the immune system. It is our hypothesis that UCAExpand