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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation.
Modifications of hepcidin gene expression suggest a key role for hepciridin in iron homeostasis under various pathophysiological conditions, which may support the pharmaceutical use of hePCidin agonists and antagonists in various ironHomeostasis disorders. Expand
Doublecortin Is a Developmentally Regulated, Microtubule-Associated Protein Expressed in Migrating and Differentiating Neurons
It is shown that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons, and Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neuron, and a strong axonal labeling is observed in differentiating neuron. Expand
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
A peculiar phenotype of Usf2−/− mice that progressively develop multivisceral iron overload is reported; plasma iron overcomes transferrin binding capacity, and nontransferrin-bound iron accumulates in various tissues including pancreas and heart. Expand
Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.
It is proposed that Apc is the liver "zonation-keeper" gene and that genes involved in the periportal urea cycle and the perivenous glutamine synthesis systems are critical targets of beta-catenin signaling. Expand
Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas.
Hepatocellular carcinoma (HCC) is the major primary malignant tumor in the human liver, but the molecular changes leading to liver cell transformation remain largely unknown. The Wnt-beta-cateninExpand
A Novel CNS Gene Required for Neuronal Migration and Involved in X-Linked Subcortical Laminar Heterotopia and Lissencephaly Syndrome
The complete disorganization observed in lissencephaly and heterotopia seems to reflect a failure of early events associated with neuron dispersion. Expand
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.
Surprisingly, despite the inhibition of hepatic lipogenesis, expression of AMPKalpha2-CA led to fatty liver due to the accumulation of lipids released from adipose tissue, and short-term AMPK activation in the liver reduces blood glucose levels and results in a switch from glucose to fatty acid utilization to supply energy needs. Expand
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation
The results demonstrate an association between cognitive impairment and a defect in a signalling pathway that depends on a Ras-like GTPase, which is known to affect cell migration and outgrowth of axons and dendrites in vivo. Expand
Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.
Six homeoproteins are established as a family of transcription factors controlling muscle formation through activation of one of its key regulators, myogenin, after it was found that the proteins that bind to the MEF3 site are homeobroteins of the Six/sine oculis family. Expand
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
The results strongly support the proposed role of hepcidin as a putative iron-regulatory hormone and the animal models devoid of or overexpressing the peptide represent valuable tools for investigating iron homeostasis in vivo and for deciphering the molecular mechanisms of hePCidin action. Expand