The measurement of total body water in the human subject by deuterium oxide dilution; with a consideration of the dynamics of deuterium distribution.
- P. R. Schloerb, B. Friis‐Hansen, I. Edelman, A. K. Solomon, F. D. Moore
- EngineeringJournal of Clinical Investigation
- 1 October 1950
The increasing availability and lowered cost of both stable and radioactive isotopes has made possible study of the total amount of liquid and solid water in the human subject.
Determination of the Effective Hydrodynamic Radii of Small Molecules by Viscometry
The effective hydrodynamic radii of small uncharged molecules in dilute aqueous solution were determined using Einstein's classical theory of viscosity using an empirical correction of the Stokes-Einstein diffusion equation using the viscometric radii.
Characterization of Biological Membranes by Equivalent Pores
- A. K. Solomon
- BiologyThe Journal of General Physiology
- 1 May 1968
Osmotic Properties of Human Red Cells
The hematocrit method as a technique for determining red cell volume under anisotonic conditions has been reexamined and has been shown, with appropriate corrections for trapped plasma, to provide a…
Permeability of Luminal Surface of Intestinal Mucosal Cells
A method has been devised to measure the permeability characteristics of the intestinal mucosal cells in the rat. The method makes use of an electrical recording balance to register changes in weight…
Properties of Hemoglobin Solutions in Red Cells
A new hypothesis has been developed from thermodynamic principles alone, which predicts that, at constant pH, the net charge on the hemoglobin molecule decreases with increased hemoglobin concentration, and could provide an electrical transducer for osmotic signals.
ION AND WATER FLUXES IN THE ILEUM OF RATS
Results have been interpreted as indicating that water movement is a passive process depending on gradients of water activity and on the rate of absorption of solute.
WATER FLOW THROUGH FROG GASTRIC MUCOSA
In infected bacteria, protein synthesis is necessary to initiate DNA synthesis but is not essential for its continuation, and the resistance to UV that characterizes infected cells near the midpoint of the latent period is not due to accumulation of DNA, but depends on some chloramphenicol-sensitive process completed at about the time the rate of DNA synthesis becomes maximal.
Determination of Equivalent Pore Radius for Human Red Cells by Osmotic Pressure Measurement
A new method has been developed to measure the equivalent pore radius in cellular membranes, and has been applied to human red cells, which requires no measurement of the rate of water entrance into the cell, and is essentially independent of the kinetics of cell swelling.
THE RATE OF EXCHANGE OF TRITIATED WATER ACROSS THE HUMAN RED CELL MEMBRANE
The flow method of reaction rate measurement has been adapted to the determination of the rate of diffusion of water into the human red cell, and the difference between these two rates of water entrance has been interpreted as indicating the presence of water-filled channels in the membrane.