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The ORF3 Protein of Porcine Circovirus Type 2 Interacts with Porcine Ubiquitin E3 Ligase Pirh2 and Facilitates p53 Expression in Viral Infection
Results show that the PCV2 ORF3 protein specifically interacts with pPirh2 and inhibits its stabilization; this may lead to increasing p53 expression, resulting in apoptosis.
c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells.
- M. Gururajan, Roger G. Chui, A. K. Karuppannan, J. Ke, C. D. Jennings, S. Bondada
- 15 August 2005
Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family, which appears to have a unique prosurvival role in the B-lymphoma model.
Porcine circoviruses: current status, knowledge gaps and challenges.
Attenuation of porcine circovirus 2 in SPF piglets by abrogation of ORF3 function.
Porcine Circovirus Type 2 (PCV2) Vaccines in the Context of Current Molecular Epidemiology
This review attempts to synthesize the understanding of PCV2 biology, experimental studies on the antigenic variability, and molecular epidemiological analysis of the evolution ofPCV2 genotypes to predict the potential increase in virulence of the emergent PCV 2 genotype and the efficacy of the current vaccines derived from PCV3a genotype against the PCV1d genotype viruses.
Enhanced replication of porcine circovirus type 2 (PCV2) in a homogeneous subpopulation of PK15 cell line.
Characterization and epitope mapping of monoclonal antibodies recognizing N-terminus of Rep of porcine circovirus type 2.
Lawsonia intracellularis: Revisiting the Disease Ecology and Control of This Fastidious Pathogen in Pigs
The potential of manipulating the gut microbiome of pigs with feed ingredients or supplements to control L. intracellularis disease burden is promising based on the current understanding of the porcine gut microbiome in general, as well as preliminary insights into the disease ecology of L. intruder infection accrued over the last 30 years.
Protective immunity against influenza H5N1 virus challenge in mice by intranasal co-administration of baculovirus surface-displayed HA and recombinant CTB as an adjuvant.