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ATP stimulates pannexin 1 internalization to endosomal compartments.
TLDR
Striking evidence is provided that ATP, in turn, stimulates internalization of Panx1 to intracellular membranes and that elevation of ATP levels diverts a sub-population to recycling endosomes. Expand
Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization
TLDR
This work uses overlap-extension cloning to create the first chimeric Panx, consisting of Panx2 with the Panx1 C-terminus (Panx2Panx1CT), and is the first to observe a high level of co-localization between Panx 2 and the endolysosomal enriched mannose-6-phosphate receptor. Expand
P2X7 receptor cross-talk regulates ATP-induced pannexin 1 internalization.
TLDR
The data suggest that extracellular ATP induces and is required for Panx1 EL1-mediated, cholesterol-dependent P2X7R-Panx1 clustering and endocytosis and have important implications for understanding the role of Pannexin 1 in the nervous system. Expand
Stress gates an astrocytic energy reservoir to impair synaptic plasticity
TLDR
It is shown in mice that stress constrains the shuttling of glucose and lactate through astrocyte networks, creating a barrier for neuronal access to anastrocytic energy reservoir in the hippocampus and neocortex, compromising long-term potentiation. Expand
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton
TLDR
The roles of pannexin 1 (Panx1) large-pore ion and metabolite channels are becoming recognized in many physiological and pathophysiological scenarios and the reciprocal regulation between Panx1 and the cytoskeleton is examined. Expand
Transcriptional and post-translational regulation of pannexins.
TLDR
The role of post-translational modifications in the regulation of trafficking and channel properties is explored, highlighting important work on glycosylation, phosphorylation, S-nitrosylation and proteolytic cleavage. Expand
Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure
TLDR
Translocalization of Panx1 to Cav1-enriched caveolae in VSMCs augments the release of purinergic stimuli necessary for proper adrenergic-mediated vasoconstriction and blood pressure homeostasis. Expand
The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability
TLDR
This work shows the catalytic FKBP domain binds microtubules (MTs) directly to promote their polymerization and stabilize the MT network, and provides evidence that FK BP25 association with chromatin is cell-cycle regulated by Protein Kinase C phosphorylation. Expand
Regulation of Pannexin 1 Surface Expression by Extracellular ATP: Potential Implications for Nervous System Function in Health and Disease
TLDR
It is proposed that ATP-induced Panx1 endocytosis could play an important role in regulating the balance of cell proliferation, survival, and differentiation within this neurogenic niche in the healthy brain. Expand
Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation
TLDR
Limiting RyR2 open time may be a hyperactivity-directed, non-β-amyloid-targeted anti-AD strategy that prevents and rescues neuronal hyperactivity, memory impairment, and neuron loss even in late stages of AD. Expand
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