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The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration.
These observations urge further study of the onset of puberty as a possible sensitive and early marker of the interactions between environmental conditions and genetic susceptibility that can influence physiological and pathological processes. Expand
Serum levels of insulin-like growth factor I and its binding proteins in health and disease.
  • A. Juul
  • Medicine
  • Growth hormone & IGF research : official journal…
  • 1 August 2003
The BoneXpert Method for Automated Determination of Skeletal Maturity
The method reconstructs, from radiographs of the hand, the borders of 15 bones automatically and then computes ldquointrinsicrdquo bone ages for each of 13 bones (radius, ulna, and 11 short bones) and transforms the intrinsic bone ages into Greulich Pyle or Tanner Whitehouse bone age. Expand
Childhood Exposure to Phthalates: Associations with Thyroid Function, Insulin-like Growth Factor I, and Growth
Positive associations between urinary phthalate concentrations and thyroid hormones, IGF-I, and growth in children were showed, which may suggest causative negative roles of phthalates exposures for child health. Expand
Pubertal development in Danish children: comparison of recent European and US data.
It is believed it is crucial to monitor the pubertal development closely in Denmark in the coming decades as obesity certainly plays a role in the timing of puberty, but the marked differences between Denmark and USA cannot be attributed exclusively to differences in BMI. Expand
Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone.
Leptin, the product of the ob gene, is thought to play a key role in the regulation of body fat mass. Beyond this function, it appears to be an integral component of variousExpand
Low Serum Insulin-Like Growth Factor I Is Associated With Increased Risk of Ischemic Heart Disease: A Population-Based Case-Control Study
Individuals without IHD but with low circulating IGF-I levels and high IGFBP-3 levels have significantly increased risk of developing IHD during a 15-year follow-up period, suggesting that IGF- I may be involved in the pathogenesis of IHD. Expand
Examination of US Puberty-Timing Data from 1940 to 1994 for Secular Trends: Panel Findings
It is concluded that altered puberty timing should be considered an adverse effect, although the magnitude of change considered adverse was not assessed and additional analyses of existing puberty-timing data are recommended to examine secular trends and trends in the temporal sequence of pubertal events. Expand
Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment
A timely diagnosis and treatment to induce puberty can be beneficial for sexual, bone and metabolic health, and might help minimize some the psychological effects of CHH. Expand
Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index.
There was a significant variation in serum IGF-I levels with age within a given Tanner stage of puberty in addition to the well known increase with increasing age or pubertal stage, which cannot be separated into simple additive components when studying 1030 children in a cross-sectional design. Expand