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Stage-specific sensitivity ofPlasmodium falciparum to antifolates
TLDR
The results support earlier reports suggesting that DNA synthesis is most pronounced in 32–42 h old trophozoites and the possible relevance of the results to the metabolism of P. falciparum is discussed.
Mechanisms of sulfadoxine resistance in Plasmodium falciparum.
The mechanism of pyrimethamine resistance in Plasmodium falciparum.
TLDR
Altered properties of plasmodial DHFR are apparently the only mechanism responsible for pyrimethamine resistance in the strain of Plasmodium falciparum studied.
14C-Desferrioxamine B: Uptake into erythrocytes infected withPlasmodium falciparum
TLDR
Results indicate that Desferrioxamine B can the red blood cell and pass through the parasite membrane and that the parasites are killed by the intracellular action of the chelator.
[15-Hydroxyprostaglandin dehydrogenase from human placenta. 1. Isolation and characterization].
TLDR
The protein in the final preparation steps showed neither alcohol dehydrogenase, NAD reductase, nor NADH oxidase activity, nor enzymatic conversion of prostaglandin or 15-oxoprostaglandIn in the absence of NAD and NADH, so no evidence for the exitstence of isoenzymes was obtained.
Stage-dependent inhibition of chloroquine on Plasmodium falciparum in vitro.
TLDR
Morphological observation of the life cycle of the malaria parasite in highly synchronous cultures after an exposure to therapeutic concentrations of chloroquine in ring, trophozoite and schizont stages found that chloroquin could not affect merozoite invasion of the erythrocytes and the determination of the IC50 showed that theIC50 of trophozites was about 6 times as high as that of rings.
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