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Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells
Previous work has shown that memory-phenotype CD44hi CD8+ cells are controlled by a cytokine, interleukin (IL)-15. However, the dependency of CD44hi CD8+ cells on IL-15 is partial rather thanExpand
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Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo.
Targeted silencing of disease-associated genes by synthetic short interfering RNA (siRNA) holds considerable promise as a novel therapeutic strategy. However, unmodified siRNA can be potent triggersExpand
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2'-O-methyl-modified RNAs act as TLR7 antagonists.
RNA molecules such as single-stranded RNA (ssRNA) and small interfering RNA (siRNA) duplexes induce Toll-like receptor (TLR)-mediated immune stimulation after intracellular delivery. We haveExpand
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siRNA and innate immunity.
Canonical small interfering RNA (siRNA) duplexes are potent activators of the mammalian innate immune system. The induction of innate immunity by siRNA is dependent on siRNA structure and sequence,Expand
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Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.
siRNAs that specifically silence the expression of cancer-related genes offer a therapeutic approach in oncology. However, it remains critical to determine the true mechanism of their therapeuticExpand
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Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation.
Activation of innate immunity has direct effects in modulating viral replication, tumor growth, angiogenesis, and inflammatory and other immunological processes. It is now established that unmodifiedExpand
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Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes.
The systemic application of nucleic acid drugs requires delivery systems that overcome the poor pharmacokinetics, limited biodistribution, and inefficient uptake of nucleic acids. PEGylated liposomesExpand
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Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2.
Histone deacetylase 2 (HDAC2) is a chromatin modifier involved in epigenetic regulation of cell cycle, apoptosis, and differentiation that is upregulated commonly in human hepatocellular carcinomaExpand
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Abstract LB-289: A phase I dose escalation study of TKM-080301, a RNAi therapeutic directed against PLK1, in patients with advanced solid tumors.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: Polo-like kinase 1 (PLK1) is a serine/threonine kinase that regulates multiple critical aspects of cellExpand
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Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice
We previously identified short synthetic shRNAs (sshRNAs) that target a conserved hepatitis C virus (HCV) sequence within the internal ribosome entry site (IRES) of HCV and potently inhibit HCVExpand
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