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Ryanodine receptors: structure, expression, molecular details, and function in calcium release.
Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum membrane and are responsible for the release of Ca(2+) from intracellular stores during excitation-contractionExpand
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Canonical and non-canonical aryl hydrocarbon receptor signaling pathways.
Decades of research on the Aryl hydrocarbon Receptor (AhR) has unveiled its involvement in the toxicity of halogenated and polycyclic aromatic hydrocarbons, and a myriad of normal physiologicalExpand
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The Tumor Suppressor Kruppel-Like Factor 6 Is a Novel Aryl Hydrocarbon Receptor DNA Binding Partner
The aryl hydrocarbon receptor (AhR) is a ligand-mediated basic helix-loop-helix transcription factor of the Per/Arnt/Sim family that regulates adaptive and toxic responses to a variety of chemicalExpand
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Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs.
The Ah receptor is a transcription factor that modulates gene expression via interactions with multiple protein partners; these are reviewed, including the novel NC-XRE pathway involving KLF6.
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AICAR Prevents Heat Induced Sudden Death in RyR1 Mutant Mice Independent of AMPK Activation
Mice with a knock-in mutation (Y524S) in the type I ryanodine receptor (Ryr1), a mutation analogous to the Y522S mutation that is associated with malignant hyperthermia in humans, die when exposed toExpand
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Ah Receptor–Mediated Suppression of Liver Regeneration through NC-XRE–Driven p21Cip1 Expression
Previous studies in hepatocyte-derived cell lines and the whole liver established that the aryl hydrocarbon receptor (AhR) can disrupt G1-phase cell cycle progression following exposure to persistentExpand
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A chemical chaperone improves muscle function in mice with a RyR1 mutation
Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca2+ release channel (RyR1) display muscle weakness and atrophy, but the underlyingExpand
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Homocitrullination Is a Novel Histone H1 Epigenetic Mark Dependent on Aryl Hydrocarbon Receptor Recruitment of Carbamoyl Phosphate Synthase 1*
Background: Characterization of a Nonconsensus xenobiotic response element (NC-XRE), a novel AhR binding site. Results: AhR binding to the NC-XRE in response to TCDD results in the recruitment ofExpand
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Identification of Stanniocalcin 2 as a Novel Aryl Hydrocarbon Receptor Target Gene
Proper hepatocyte function is vital for survival; thus, unrepaired destruction of the parenchymal tissue leading to liver decompensation is devastating. Therefore, understanding the homeostaticExpand
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Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1.
The Na+/dicarboxylate cotransporter 1 (NaDC1) is a low-affinity transporter for citric acid cycle intermediates such as succinate and citrate. The sequence of NaDC1 contains a number of conservedExpand
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