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Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide.
Membrane metallo-endopeptidase (NEP; neutral endopeptidase, kidney-brush-border neutral proteinase, enkephalinase, EC 3.4.24.11) cleaves peptides at the amino side of hydrophobic amino acids. WhileExpand
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Release of Histamine from Mast Cells by Vasoactive Peptides 1
  • A. Johnson, E. Erdös
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental…
  • 1 April 1973
Summary The effect of a variety of synthetic peptides on rat mast cells was investigated. Peptides with two or more basic groups were active histamine releasers, while eledoisin, angiotensin I andExpand
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Stimulation of prostaglandin formation by vasoactive mediators in cultured human endothelial cells.
Human endothelial cells in culture synthesize prostaglandins and release these products into the culture medium. The major products of arachidonic acid metabolism were identified by high pressureExpand
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The effect of intravenous infusions of sterculic acid on milk fat synthesis.
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Differential expression of the urokinase receptor in fibroblasts from normal and fibrotic human lungs.
Binding of urokinase-type plasminogen activator (uPA) to a specific receptor (uPAR) on human lung fibroblasts enables it to regulate cellular proteolysis and remodeling of the extracellular matrix.Expand
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Inhibition by cyclopropene fatty acids of the desaturation of stearic acid in hen liver
The mechanism of the hardening of body fats of animals by dietary lipids which contain cyclopropene fatty acids has been studied. Dietary methyl sterculate increased the stearic acid content of eggExpand
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Neutral metalloendopeptidase in human lung tissue and cultured cells.
The distribution of a neutral metalloendopeptidase (NEP), or "enkephalinase," in human lung tissue and cultured cells was compared with that of angiotensin I converting enzyme (ACE). The specificExpand
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Human pulmonary endothelial cells in culture. Activities of cells from arteries and cells from veins.
  • A. Johnson
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1 April 1980
Endothelial cells were cultured from various different human vessels, including aortas, pulmonary, ovarian, and umbilical arteries, and pulmonary, ovarian, and umbilical veins. The cultured cellsExpand
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Release of histamine from rat mast cells by the complement peptides C3a and C5a.
Suspensions of rat mast cells were used to study the histamine-releasing actions of anaphylatoxins C3A and C5a in vitro. The peptides, derived from human or porcine complement proteins C3 and C5,Expand
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Enzymes in placental microvilli: Angiotensin I converting enzyme, angiotensinase A, carboxypeptidase, and neutral endopeptidase (“enkephalinase”)
Microvilli from human placental syncytiotrophoblast are rich in angiotensin I converting enzyme (ACE), aminopeptidase A, a carboxypeptidase N-like enzyme, and a neutral endopeptidase (NEP). TheExpand
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