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Strains and Strategies for Large-Scale Gene Deletion Studies of the Diploid Human Fungal Pathogen Candida albicans
ABSTRACT Candida albicans is the most common human fungal pathogen and causes significant morbidity and mortality worldwide. Nevertheless, the basic principles of C. albicans pathogenesis remainExpand
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White-Opaque Switching in Candida albicans Is Controlled by Mating-Type Locus Homeodomain Proteins and Allows Efficient Mating
Discovered over a decade ago, white-opaque switching in the human fungal pathogen Candida albicans is an alternation between two quasistable, heritable transcriptional states. Here, we show thatExpand
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Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution
Cataloging Kinase Targets Protein phosphorylation is a central mechanism in the control of many biological processes (see the Perspective by Collins). It remains a challenge to determine the completeExpand
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A Phenotypic Profile of the Candida albicans Regulatory Network
Candida albicans is a normal resident of the gastrointestinal tract and also the most prevalent fungal pathogen of humans. It last shared a common ancestor with the model yeast SaccharomycesExpand
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Control of filament formation in Candida albicans by the transcriptional repressor TUP1.
The pathogenic yeast Candida albicans regulates its cellular morphology in response to environmental conditions. Ellipsoidal, single cells (blastospores) predominate in rich media, whereas filamentsExpand
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Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissectionExpand
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A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
A biofilm is an organized, resilient group of microbes in which individual cells acquire properties, such as drug resistance, that are distinct from those observed in suspension cultures. Here, weExpand
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Identification and characterization of TUP1-regulated genes in Candida albicans.
TUP1 encodes a transcriptional repressor that negatively controls filamentous growth in Candida albicans. Using subtractive hybridization, we identified six genes, termed repressed by TUP1 (RBT),Expand
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NRG1, a repressor of filamentous growth in C.albicans, is down‐regulated during filament induction
In response to a variety of external signals, the fungal pathogen Candida albicans undergoes a transition between ellipsoidal single cells (blastospores) and filaments composed of elongated cellsExpand
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Net1, a Sir2-Associated Nucleolar Protein Required for rDNA Silencing and Nucleolar Integrity
The Sir2 protein mediates gene silencing and repression of recombination at the rDNA repeats in budding yeast. Here we show that Sir2 executes these functions as a component of a nucleolar complexExpand
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