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Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota.
Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra
Analysis of products of oxidation and deamination of all four DNA bases in control and PD brains showed that levels of 8‐hydroxyguanine (8‐OHG) tended to be elevated and levels of 2,6‐diamino‐4‐Hydroxy‐5‐formamidopyrimidine (FAPy guanine) tendedto be decreased in PD, but the most striking difference was a rise in 8‐ OHG in PD substantia nigra.
An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease
The finding of increased oxidative damage to protein and DNA strengthens the possibility that oxidative damage may play a role in the pathogenesis of AD in at least some key brain regions.
Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
It is argued that tocopherols and tocotrienols may also exert direct beneficial effects in the gastrointestinal tract and that their return to theintestinal tract by the liver through the bile may be physiologically advantageous.
Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds.
Base modification and strand breakage in isolated calf thymus DNA and in DNA from human skin epidermal keratinocytes exposed to peroxynitrite or 3-morpholinosydnonimine.
- J. Spencer, J. Wong, A. Jenner, O. Aruoma, C. Cross, B. Halliwell
- Biology, ChemistryChemical research in toxicology
- 15 October 1996
Large increases in xanthine and hypoxanthine, possible deamination products of guanine and adenine, respectively, and in 8-nitroguanine were observed, which suggests that hydroxyl radicals were not major contributors to base modification caused by peroxynitrite, as OH is known to cause multiple oxidative modifications to all four DNA bases.
A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2'-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction.
- Hai‐Shu Lin, A. Jenner, C. Ong, S. Huang, M. Whiteman, B. Halliwell
- BiologyBiochemical Journal
- 1 June 2004
A sensitive method for the quantification of 8OHdG in urine by single solid-phase extraction and GC-MS (gas chromatography with MS detection) using selective ion monitoring is described in the present study and seems suitable to be used as a routine methodology for the measurement of urinary excretion of 7-hydroxy-2'-deoxyguanosine in large population studies.
Rapid preparation of human urine and plasma samples for analysis of F2-isoprostanes by gas chromatography-mass spectrometry.
Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex
The data indicate that changes in lipid metabolism occur in the Parkinson's disease visual cortex in the absence of obvious pathology, which suggests that normalization of lipid metabolism and/or oxidative stress status in the visual cortex may represent a novel route for treatment of non-motor symptoms, such as visual hallucinations, that are experienced by a majority of Parkinson's patients.