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Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra
- Z. Alam, A. Jenner, +5 authors B. Halliwell
- Chemistry, MedicineJournal of neurochemistry
- 1 September 1997
Analysis of products of oxidation and deamination of all four DNA bases in control and PD brains showed that levels of 8‐hydroxyguanine (8‐OHG) tended to be elevated and levels of 2,6‐diamino‐4‐Hydroxy‐5‐formamidopyrimidine (FAPy guanine) tendedto be decreased in PD, but the most striking difference was a rise in 8‐ OHG in PD substantia nigra.
Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota.
- Hui Cheng Lee, A. Jenner, C. Low, Yuan-Kun Lee
- Biology, MedicineResearch in microbiology
- 1 November 2006
The observations provide further evidence for the importance of colonic bacteria in the metabolism, absorption and potential activity of phenolics in human health and disease and suggest that different phenolics may play an important role in the maintenance of gastrointestinal health.
An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease
- L. Lyras, N. Cairns, A. Jenner, P. Jenner, B. Halliwell
- Biology, MedicineJournal of neurochemistry
- 1 May 1997
The finding of increased oxidative damage to protein and DNA strengthens the possibility that oxidative damage may play a role in the pathogenesis of AD in at least some key brain regions.
Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
- B. Halliwell, J. Rafter, A. Jenner
- Chemistry, MedicineThe American journal of clinical nutrition
It is argued that tocopherols and tocotrienols may also exert direct beneficial effects in the gastrointestinal tract and that their return to theintestinal tract by the liver through the bile may be physiologically advantageous.
Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds.
This study is the first to measure the range of aromatic compounds in human fecal water and demonstrates that phenolic acid concentrations are high, indicating that the biological effects of phenolics may play an important role in colon function.
Base modification and strand breakage in isolated calf thymus DNA and in DNA from human skin epidermal keratinocytes exposed to peroxynitrite or 3-morpholinosydnonimine.
- J. Spencer, J. Wong, A. Jenner, O. Aruoma, C. Cross, B. Halliwell
- Chemistry, MedicineChemical research in toxicology
- 15 October 1996
Large increases in xanthine and hypoxanthine, possible deamination products of guanine and adenine, respectively, and in 8-nitroguanine were observed, which suggests that hydroxyl radicals were not major contributors to base modification caused by peroxynitrite, as OH is known to cause multiple oxidative modifications to all four DNA bases.
A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2'-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction.
- Hai-Shu Lin, A. Jenner, C. Ong, S. Huang, M. Whiteman, B. Halliwell
- Chemistry, MedicineThe Biochemical journal
- 1 June 2004
A sensitive method for the quantification of 8OHdG in urine by single solid-phase extraction and GC-MS (gas chromatography with MS detection) using selective ion monitoring is described in the present study and seems suitable to be used as a routine methodology for the measurement of urinary excretion of 7-hydroxy-2'-deoxyguanosine in large population studies.
Rapid preparation of human urine and plasma samples for analysis of F2-isoprostanes by gas chromatography-mass spectrometry.
- C. J. Lee, A. Jenner, B. Halliwell
- Chemistry, MedicineBiochemical and biophysical research…
- 30 July 2004
A quick sample purification method using anion exchange SPE extraction for F2-isoprostane showed recovery of 55-65% and high linearity for concentration 0-1.0 ng/ml for urine and plasma and 0-0.007 ng/mg creatinine for plasma and urine, respectively.
Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease
- L. Lim, V. Jackson-Lewis, +7 authors M. Wenk
- Biology, MedicineCell Death and Differentiation
- 5 August 2011
It is found that lanosterol induces mild depolarization of mitochondria and promotes autophagy, and this results highlight a novel sterol-based neuroprotective mechanism with direct relevance to PD.
Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: protection by chronic oral intake of resveratrol.
- Y. T. Wong, J. Gruber, A. Jenner, M. Ng, R. Ruan, F. Tay
- Chemistry, MedicineFree radical biology & medicine
- 15 March 2009
It is suggested that chronic RSV treatment may induce nephrotoxicity, as demonstrated that a 12-month RSV intake resulted in significant elevation of 8-iso-PGF(2 alpha) and PCC in kidney.