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Hypervariable ‘minisatellite’ regions in human DNA
The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–15-base pair ‘core’ sequence similar to the generalized recombination signal (χ) ofExpand
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Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex
There is considerable interest in understanding patterns of linkage disequilibrium (LD) in the human genome, to aid investigations of human evolution and facilitate association studies in complexExpand
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Individual-specific ‘fingerprints’ of human DNA
Simple tandem-repetitive regions of DNA (or ‘minisatellites’) which are dispersed in the human genome frequently show substantial length polymorphism arising from unequal exchanges which alter theExpand
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PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans
PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in humans and mice. PRDM9 contains a zinc finger array that, in humans, can recognize a shortExpand
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Isolation of human simple repeat loci by hybridization selection.
We have isolated short tandem repeat arrays from the human genome, using a rapid method involving filter hybridization to enrich for tri- or tetranucleotide tandem repeats. About 30% of clones fromExpand
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Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA
Tandem-repetitive minisatellite regions in vertebrate DNA frequently show substantial allelic variation in the number of repeat units. This variation is thought to arise through processes such asExpand
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Human minisatellite mutation rate after the Chernobyl accident
Germline mutation at human minisatellite loci has been studied among children born in heavily polluted areas of the Mogilev district of Belarus after the Chernobyl accident and in a controlExpand
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Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations
PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our view of PRDM9Expand
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Human recombination hot spots hidden in regions of strong marker association
The fine-scale distribution of meiotic recombination events in the human genome can be inferred from patterns of haplotype diversity in human populations but directly studied only by high-resolutionExpand
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