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Pharmacokinetics of methamphetamine self-administered to human subjects by smoking S-(+)-methamphetamine hydrochloride.
S-(+)-methamphetamine hydrochloride ("ice") is abused by smoking (inhaling the vapors of the material). Male human volunteers inhaled the drug from a pipe heated at 300 degrees-305 degrees C for anExpand
Metabolism, disposition and excretion of [14C]melamine in male Fischer 344 rats.
The metabolism, excretion and disposition of melamine were determined after administration of a single oral dose of 0.025 mCi (0.38 mg) [14C]melamine to adult male Fischer 344 rats. Within the firstExpand
Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking.
The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si). Metabolism,Expand
Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men.
BACKGROUND Soy isoflavones are potential cancer chemoprevention treatments. OBJECTIVE We conducted safety studies of purified unconjugated genistein, daidzein, and glycitein, and definedExpand
Ethanol/cocaine interaction: cocaine and cocaethylene plasma concentrations and their relationship to subjective and cardiovascular effects.
To investigate the pharmacologic effects of the interaction between ethanol and cocaine, eleven male, paid volunteers familiar with the use of both ethanol and cocaine were tested in a dose-response,Expand
Pharmacokinetics of oral methamphetamine and effects of repeated daily dosing in humans.
The pharmacokinetics of orally administered S-(+)-methamphetamine-d3 were investigated in human male volunteers before and after a 13-day course of a slow release form of S-methamphetamineExpand
Biotransformation products of 3,4,4'-trichlorocarbanilide in rat, monkey, and man.
  • C. Birch, R. Hiles, +6 authors M. Wall
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 March 1978
3,4,4'-Trichlorocarbanilide (TCC), uniformly labeled with 14C in the monochloro ring, was administered to rats, rhesus monkeys, and humans. Radioactive materials in the plasma and urine of all threeExpand
Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration.
Workplace exposure to 1-bromopropane (1-BrP) can potentially occur during its use in spray adhesives, fats, waxes, and resins. 1-BrP may be used to replace ozone depleting solvents, resulting in anExpand
Interaction between marihuana and ethanol: effects on psychomotor performance.
This is a report of the results of a placebo-controlled study in which the effects of the interaction between ethanol and marihuana on drug plasma concentrations, subjective ratings of intoxication,Expand
Clinical effects of daily methamphetamine administration.
This study investigated alterations in the disposition and pharmacodynamics of methamphetamine HCl after daily administration. Six male paid volunteers familiar with the use of amphetaminesExpand