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Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles.
Doxorubicin physical state in solution and inside liposomes loaded via a pH gradient.
Generation of multilamellar and unilamellar phospholipid vesicles
Controlling the Physical Behavior and Biological Performance of Liposome Formulations Through Use of Surface Grafted Poly(ethylene Glycol)
All aspects of PEG are examined in order to gain a better understanding of how the polymer fulfills its biological role and the physical and chemical properties of the polymer are explored and compared to properties of other hydrophilic polymers.
Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
Fixing synergistic drug ratios in pharmaceutical carriers provides an avenue by which anticancer drug combinations can be optimized prospectively for maximum therapeutic activity during preclinical development and differs from current practice in which dosing regimens are developed empirically in late-stage clinical trials based on tolerability.
Unusual lipid structures selectively reduce the toxicity of amphotericin B.
Studies utilizing freeze-etch electron microscopy, differential scanning calorimetry, 31P NMR, x-ray diffraction, and optical spectroscopy revealed that this toxicity attenuation is related to the macromolecular structure of the complexes in a definable fashion.
Novel multilayered lipid vesicles: comparison of physical characteristics of multilamellar liposomes and stable plurilamellar vesicles.
It is demonstrated that, contrary to what has been assumed, classical MLVs exclude solutes during their formation and, thus, are under a state of osmotic compression; by contrast, the SPLV process produces liposomes that are not compressed.
Optimizing combination chemotherapy by controlling drug ratios.
The translation of in vitro information on synergistic drug ratios is translated into improved anticancer combination therapies in which the desired drug ratio can be controlled and maintained following administration in vivo, so that synergistic effects can be exploited.
Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity.
A Pharmacokinetic Study of Amphotericin B Lipid Complex Injection (Abelcet) in Patients with Definite or Probable Systemic Fungal Infections
- A. Adedoyin, C. Swenson, R. Branch
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 October 2000
The results showed that AMB exhibited multiexponential disposition with high clearance, large volume of distribution at steady state, and long apparent elimination half-life but no evidence of accumulation in the blood after multiple daily doses, reinforcing the suggestion that ABLC may exist as a depot in the tissues from which free AMB is slowly released to limit exposure.