Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
The Endomorphin System and Its Evolving Neurophysiological Role
- J. Fichna, A. Janecka, J. Costentin, J. do Rego
- Biology, Medicine
- Pharmacological Reviews
- 1 March 2007
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are two endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid receptor. The… Expand
Opioid receptors and their ligands.
- A. Janecka, J. Fichna, T. Janecki
- Chemistry, Medicine
- Current topics in medicinal chemistry
- 2004
This review gives a historical perspective, summarizing approximately 25 years of research on opioids. The "typical" opioid peptides produced in the brain, "atypical" opioids encrypted in milk… Expand
The role of morphine in regulation of cancer cell growth
- K. Gach, A. Wyrębska, J. Fichna, A. Janecka
- Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 29 July 2011
Morphine is considered the “gold standard” for relieving pain and is currently one of the most effective drugs available clinically for the management of severe pain associated with cancer. In… Expand
Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating κ‐opioid and cannabinoid receptors
- J. Fichna, R. Schicho, +7 authors M. A. Storr
- Chemistry, Medicine
- Neurogastroenterology and motility : the official…
- 1 December 2009
Abstract The major active ingredient of the plant Salvia divinorum, salvinorin A (SA) has been used to treat gastrointestinal (GI) symptoms. As the action of SA on the regulation of colonic function… Expand
Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors*
Background: Salvinorin A (SA) has a potent inhibitory action on mouse gastrointestinal (GI) motility and ion transport, mediated primarily by kappa‐opioid receptors (KOR). The aim of the present… Expand
A new face of endocannabinoids in pharmacotherapy. Part II: role of endocannabinoids in inflammation-derived cardiovaascular diseases.
- M. Zubrzycki, A. Liebold, A. Janecka, M. Zubrzycka
- Medicine
- Journal of physiology and pharmacology : an…
- 1 April 2014
Endocannabinoids play an important role in cardiovascular diseases caused by inflammatory disorders. Endocannabinoids are endogenous bioactive lipids that activate cannabinoid receptors and together… Expand
The role of oxidative stress in anticancer activity of sesquiterpene lactones
- K. Gach, A. Długosz, A. Janecka
- Biology, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 6 February 2015
Sesquiterpene lactones (SLs) are plant-derived compounds that are abundant in plants of the Asteraceae family and posses a broad spectrum of biological activities, ranging from anti-inflammatory,… Expand
Clinical and Molecular Features of Laron Syndrome, A Genetic Disorder Protecting from Cancer.
- A. Janecka, Marta Kołodziej-Rzepa, B. Biesaga
- Medicine, Biology
- In vivo
- 1 July 2016
Laron syndrome (LS) is a rare, genetic disorder inherited in an autosomal recessive manner. The disease is caused by mutations of the growth hormone (GH) gene, leading to GH/insulin-like growth… Expand
Enzymatic degradation of endomorphins
- A. Janecka, Renata Staniszewska, K. Gach, J. Fichna
- Chemistry, Medicine
- Peptides
- 1 November 2008
Centrally acting plant opiates, such as morphine, are the most frequently used analgesics for the relief of severe pain, even though their undesired side effects are serious limitation to their… Expand
Transient Receptor Potential Vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?
- J. Fichna, A. Mokrowiecka, +5 authors M. Storr
- Medicine
- Neurogastroenterology and motility : the official…
- 1 November 2012
Recent reports suggested that the activation of Transient Receptor Potential Vanilloid 4 (TRPV4) receptors in the gastrointestinal tract has pro‐inflammatory effects. In this study, we demonstrated… Expand