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The Endomorphin System and Its Evolving Neurophysiological Role

The relationship between these two μ-opioid receptor-selective peptides and endogenous neurohormones and neurotransmitters is described and the role of endomorphins from the physiological point of view is evaluated.
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Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors*

The results suggest that the drugs based on the structure of SA have the potential to become valuable antiinflammatory or analgesic therapeutics for the treatment of GI diseases.
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Opioid receptors and their ligands.

The main focus is on the structure-activity relationship studies of peptide ligands for three main opioid receptor types (micro, delta, kappa), their selectivities and pharmacological activities in vitro, and chemical modifications that led to obtaining potent and selective agonists and antagonists for these receptors.
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The role of morphine in regulation of cancer cell growth

An update on the influence of morphine on the growth and migration potential of tumor cells and various signaling pathways have been suggested to be involved in these extra-analgesic effects of morphine.
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Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating κ‐opioid and cannabinoid receptors

Salvinorin A slows colonic motility in vitro and in vivo and influences neurogenic ion transport and may be useful drugs in the treatment of lower GI disorders associated with increased GI transit and diarrhoea.
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The role of oxidative stress in anticancer activity of sesquiterpene lactones

The mechanisms and pathways involved in oxidative stress-induced anticancer activity of SL are described, which can affect intracellular redox signaling pathways and be considered an interesting approach for cancer treatment.
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Clinical and Molecular Features of Laron Syndrome, A Genetic Disorder Protecting from Cancer.

Patients with LS have characteristic biochemical features, such as a high serum level of GH and low IGF1 concentration, and suffer from hypoglycemia, hypercholesterolemia and sleep disorders, but surprisingly have a very low cancer risk.
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A new face of endocannabinoids in pharmacotherapy. Part II: role of endocannabinoids in inflammation-derived cardiovaascular diseases.

The results obtained to date suggest the involvement of endocannabinoids in the pathology of many cardiovascular diseases associated with inflammation, such as atherosclerosis, restenosis, chemotherapy-induced myocardial injury, diabetic and hepatic cirrhosis cardiomyopathy.
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Enzymatic degradation of endomorphins

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Characterization and distribution of NKD, a receptor for Drosophila tachykinin-related peptide 6

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