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Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
PHARMACOLOGICALLY evoked selective degeneration of neurones with a specific function or functioning with known transmitter substances, has been reported only in the monoaminergic neurone systems1,2.… Expand
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin.
Stimulation and desensitization of the hypothalamic heat‐sensitive structures by capsaicin in rats
1. In rats the injection of capsaicin into the pre‐optic area of the anterior hypothalamus produces a prompt fall in body temperature and abolishes shivering. With repeated injections of capsaicin… Expand
The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat.
Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea‐pigs
1. In rats and guinea‐pigs a subcutaneous or intraperitoneal injection of capsaicin, the substance responsible for the pungency of red pepper, produces profound hypothermia associated with skin… Expand
Mitochondrial Changes in Preoptic Neurones after Capsaicin Desensitization of the Hypothalamic Thermodetectors in Rats
CAPSAICIN, the pungent principle in red pepper (paprika), is a potent irritant causing a sensation of burning pain. After initial violent stimulation, however, this substance induces a selective… Expand
Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents.
A quantitative method for measuring the efficiency of pungent agents of capsaicin-type by the pain reaction elicited on the eye of rats is described. About 50 derivatives -- most of them amides or… Expand
Direct evidence for an axonal site of action of capsaicin
- G. Jancsó, E. Király, A. Jancsó-Gábor
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 1 August 1980
Summary1.Local application of capsaicin to the sciatic nerve of rats induced a long-lasting increase in the nociceptive threshold as tested by the hot-plate method, and prevented neurogenic… Expand
Sensory effects of capsaicin congeners. Part II: Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds.
The characteristic insensitivity of sensory nerve endings to chemically induced pain brought about by capsaicin could be reproduced on the rat's eye by pungent vanillylamides,… Expand
Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin.