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Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
PHARMACOLOGICALLY evoked selective degeneration of neurones with a specific function or functioning with known transmitter substances, has been reported only in the monoaminergic neurone systems1,2.Expand
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Stimulation and desensitization of the hypothalamic heat‐sensitive structures by capsaicin in rats
1. In rats the injection of capsaicin into the pre‐optic area of the anterior hypothalamus produces a prompt fall in body temperature and abolishes shivering. With repeated injections of capsaicinExpand
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Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea‐pigs
1. In rats and guinea‐pigs a subcutaneous or intraperitoneal injection of capsaicin, the substance responsible for the pungency of red pepper, produces profound hypothermia associated with skinExpand
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Mitochondrial Changes in Preoptic Neurones after Capsaicin Desensitization of the Hypothalamic Thermodetectors in Rats
CAPSAICIN, the pungent principle in red pepper (paprika), is a potent irritant causing a sensation of burning pain. After initial violent stimulation, however, this substance induces a selectiveExpand
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Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents.
A quantitative method for measuring the efficiency of pungent agents of capsaicin-type by the pain reaction elicited on the eye of rats is described. About 50 derivatives -- most of them amides orExpand
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Direct evidence for an axonal site of action of capsaicin
Summary1.Local application of capsaicin to the sciatic nerve of rats induced a long-lasting increase in the nociceptive threshold as tested by the hot-plate method, and prevented neurogenicExpand
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Sensory effects of capsaicin congeners. Part II: Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds.
The characteristic insensitivity of sensory nerve endings to chemically induced pain brought about by capsaicin could be reproduced on the rat's eye by pungent vanillylamides,Expand
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