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Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells
TLDR
The findings demonstrate that hypoxic exosomes induce differential gene expression in recipient glioma cells, many of which are involved in cancer progression and treatment resistance mechanisms. Expand
E1A-induced apoptosis does not prevent replication of adenoviruses with deletion of E1b in majority of infected cancer cells
TLDR
The results of this study imply that, in addition to inhibiting E1A-induced apoptosis, E1B proteins may contribute other important roles in the viral life cycle. Expand
Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature
TLDR
The overall results suggest feasibility of using a clinical or subclinical radiation dose to increase expression of the galectin-1 receptor on the tumor microvasculature to promote delivery of therapeutics via the anginex peptide. Expand
In Vivo Flow Cytometry of Circulating Tumor-Associated Exosomes
TLDR
In vivo integrated photoacoustic (PA) and fluorescence flow cytometry (PAFFC) platform can provide the detection of melanoma and breast-cancer-associated single CTPs with endogenously expressed melanin and genetically engineered proteins or exogenous dyes as PA and fluorescent contrast agents. Expand
Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines.
TLDR
It is demonstrated for the first time that a significant amount of extracellular glutathione is directly derived from glutamine, adding yet another important function to the already known glutamine dependence of tumor cells and probably tumors as well. Expand
Mild temperature hyperthermia and radiation therapy: Role of tumour vascular thermotolerance and relevant physiological factors
TLDR
It is hypothesised that heat treatments every 2 to 3 days combined with traditional or accelerated radiation fractionation may be maximally effective in exploiting the improved perfusion and oxygenation induced by typical thermal doses given in the clinic. Expand
Gene expression profiling of E2F-1-induced apoptosis.
TLDR
This study uses a quantitative microarray assay to identify the genes regulated by E2F-1 in melanoma cells and confirms changes in expression of 17 of these genes confirmed by quantitative real-time polymerase chain reaction (PCR). Expand
Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models.
TLDR
It is demonstrated that TNF-labeled gold nanoparticles combined with single or fractionated high-dose radiation therapy is effective in reducing IFP and tumor growth and shows promise for clinical translation. Expand
In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma
TLDR
The high sensitivity of the Cytophone technology using an in vivo photoacoustic flow cytometry platform with a high pulse rate laser and focused ultrasound transducers for label-free detection of melanin-bearing CTCs in patients with melanoma is demonstrated. Expand
In Vivo Long-Term Monitoring of Circulating Tumor Cells Fluctuation during Medical Interventions
TLDR
To prevent side effects of medical interventions, the defined dynamics of intervention-induced CTCs may be used as a basis for initiation of aggressive anti-CTC therapy at time-points of increasing CTC number. Expand
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