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Fatty acid elongases in mammals: their regulation and roles in metabolism.
A significant amount of the fatty acids synthesized by the cytosolic enzyme complex fatty acid synthase (FAS) or taken up by the diet are further elongated into very long chain fatty acids (VLCFA) inExpand
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Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
The mitochondrial uncoupling protein (UCP) in the mitochondrial inner membrane of mammalian brown adipose tissue generates heat by uncoupling oxidative phosphorylation1. This process protects againstExpand
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The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.
In mammalian cells, elongases and desaturases play critical roles in regulating the length and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In the pastExpand
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Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold
Adaptive nonshivering thermogenesis may have profound effects on energy balance and is therefore therefore is a potential mechanism for counteracting the development of obesity. The molecular basisExpand
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UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.
The uniqueness of UCP1 (as compared to UCP2/UCP3) is evident from expression analysis and ablation studies. UCP1 expression is positively correlated with metabolic inefficiency, being increased byExpand
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Role of a New Mammalian Gene Family in the Biosynthesis of Very Long Chain Fatty Acids and Sphingolipids
Whereas the physiological significance of microsomal fatty acid elongation is generally appreciated, its molecular nature is poorly understood. Here, we describe tissue-specific regulation of a novelExpand
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Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent
To examine the thermogenic significance of the classical uncoupling protein-1 (UCP1), the thermogenic potential of brown adipocytes isolated from UCP1-ablated mice was investigated.Ucp1(−/−) cellsExpand
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Native UCP1 Displays Simple Competitive Kinetics between the Regulators Purine Nucleotides and Fatty Acids*
Elucidation of the regulation of uncoupling protein 1 (UCP1) activity in its native environment, i.e. the inner membrane of brown-fat mitochondria, has been hampered by the presence ofExpand
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Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses
Specialized proresolving lipid mediators reduce human T cell activation and prevent TH1 and TH17 cell differentiation from naïve T cells while promoting de novo Treg induction. Naïve T cells nudgedExpand
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Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation.
The expression of the Elovl3 gene, which belongs to the Elovl gene family coding for microsomal enzymes involved in very long-chain fatty acid (VLCFA) elongation, is dramatically increased in mouseExpand
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