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Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library
TLDR
This work shows that conventional hybridoma technology may be superseded by large phage libraries that are proving to be a stable and reliable source of specific, high affinity human monoclonal antibodies. Expand
PD‐L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD‐L1 IHC Assay Comparison Project
TLDR
The Blueprint PD‐L1 IHC Assay Comparison Project revealed that three of the four assays were closely aligned on tumor cell staining whereas the fourth showed consistently fewer tumor cells stained, indicating that interchanging assays and cutoffs would lead to “misclassification” of PD‐ L1 status for some patients. Expand
Molecular Diversity of Rumen Methanogens from Sheep in Western Australia
TLDR
The molecular diversity of rumen methanogens in sheep in Australia was investigated by using individual 16S rRNA gene libraries prepared from the rumen contents obtained from six merino sheep grazing pasture, and five sheep fed a lucerne hay-based diet. Expand
Characterization of GATA3 Mutations in the Hypoparathyroidism, Deafness, and Renal Dysplasia (HDR) Syndrome*
TLDR
The results, which expand the spectrum of HDR-associated GATA3 mutations and report the first acceptor splice site mutation, help to elucidate the molecular mechanisms that alter the function of this zinc finger transcription factor and its role in causing this developmental anomaly. Expand
Prospective Study of Effect of Androgens on Serum Inflammatory Markers in Men
TLDR
Exogenous androgen therapy with or without increased estradiol levels does not alter serum inflammatory markers in older men; this finding is in contrast to the effects of estrogens on inflammatory markers that have been found in postmenopausal women. Expand
Development and Validation of a Real-Time PCR Method To Quantify Rumen Protozoa and Examination of Variability between Entodinium Populations in Sheep Offered a Hay-Based Diet
ABSTRACT PCR and real-time PCR primers for the 18S rRNA gene of rumen protozoa (Entodinium and Dasytricha spp.) were designed, and their specificities were tested against a range of rumen microbesExpand
Fish oil metabolism in ruminants III. Transfer of n−3 polyunsaturated fatty acids (PUFA) from tuna oil into sheep's milk
TLDR
An approach that enables enrichment of milk with health-enhancing fatty acids without deleterious consequences on milk yield or composition is provided. Expand
Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival.
TLDR
The link between systemic and intraperitoneal inflammation with regards to peritoneal membrane function and patient survival is determined as part of the Global Fluid Study, a multinational, multicenter, prospective, combined incident and prevalent cohort study with up to 8 years of follow-up. Expand
Influence of duration of supplementation with ruminally protected linseed oil on the fatty acid composition of feedlot lambs
TLDR
The PLO supplement was effective in significantly enriching lamb meat with n-3 PUFA in three weeks, but longer periods were required to increase the levels of the longer chain PUFAs that are required for “source claim” and product differentiation. Expand
Use of HLA typing in diagnosing celiac disease in patients with type 1 diabetes.
TLDR
The prevalence of Celiac disease among patients with type 1 diabetes is higher than previously estimated in Australia and TTGA is a valuable diagnostic tool that can be used for screening celiac disease in patients withtype 1 diabetes. Expand
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