Share This Author
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.
Complementation analysis in vitro of rodent CGs is accomplished by pairwise mixing of mutant extracts, and results show that mutants from groups 2, 3, 5 and XP‐A can complement all other CGs tested, however, selective non‐complementation in vitro was observed in mutual mixtures of groups 1, 4, 11 andXP‐F, suggesting that the complementing activities involved somehow affect each other.
Resolution of cutaneous inflammation after local elimination of macrophages
- T. Thepen, A. J. Vuuren, R. Kiekens, C. Damen, W. Vooijs, J. G. Winkel
- Biology, MedicineNature Biotechnology
An immunotoxin, composed of an antibody directed against the high-affinity IgG receptor CD64 and Ricin-A, was constructed with the aim of resolving chronic inflammation through elimination of activated macrophages, and proved very efficient in inducing apoptosis in activated Macrophages.
Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH).
The role of ERCC3 and probably the entire BTF2 complex in transcription in vivo which was hitherto only demonstrated in vitro is established and strongly suggests that transcription itself is a critical component for maintenance of chromatin structure.
Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi‐ethnic European city
- W. J. Hollander, I. Holster, E. Kuipers
- MedicineJournal of gastroenterology and hepatology
- 1 November 2013
It is shown that immigrants from developing countries with high H. pylori prevalence have settled in Western urban areas and may help in realizing a more selective approach to assess H. pylori‐related diseases in a migrant community.
Serum hepatitis B virus RNA predicts response to peginterferon treatment in HBeAg‐positive chronic hepatitis B
It is concluded that early on‐treatment HBV RNA level may be used to predict nonresponse to peginterferon treatment, and declines profoundly during PEG‐IFN treatment.
A Randomized Trial of Peginterferon α-2a With or Without Ribavirin for HBeAg-Negative Chronic Hepatitis B
- V. Rijckborst, M. Borg, H. Janssen
- Medicine, BiologyThe American Journal of Gastroenterology
- 1 August 2010
Treatment with peginterferon α-2a resulted in a limited sustained response rate in HBeAg-negative chronic hepatitis B patients, and combination therapy was well tolerated, although it was associated with a higher risk of anemia and neutropenia.
Pharmacogenetics of thiopurine therapy in paediatric IBD patients
The occurrence and type of adverse events to azathioprine may be related to thiopurine S‐methyltransferase (TPMT) enzyme activity and to inosine triphophate pyrophosphatase (ITPase) deficiency.
The human Fc receptor for IgA (FcαRI, CD89) on transgenic peritoneal macrophages triggers phagocytosis and tumor cell lysis
Precore and core promoter mutants are associated with higher HBeAg seroconversion but low disease remission rates in HBV patients treated with nucleos(t)ide analogues
HBeAg seroconversion in HBV patients is considered an important event. We determined precore (PC) and base core promoter (BCP) mutations in 137 HBeAg‐positive nucleos(t)ide analogues (NA) treated…
Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18)
Remarkably, the capacity to lyse tumor targets was ablated in hFcRI transgenic/ CR3−/− mice, although binding of neutrophils to tumor cells was intact, which shows a previously unrecognized importance of CR3 for hF cRI-mediated antibody-dependent cellular cytotoxicity (ADCC).