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Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.
TLDR
Complementation analysis in vitro of rodent CGs is accomplished by pairwise mixing of mutant extracts, and results show that mutants from groups 2, 3, 5 and XP‐A can complement all other CGs tested, however, selective non‐complementation in vitro was observed in mutual mixtures of groups 1, 4, 11 andXP‐F, suggesting that the complementing activities involved somehow affect each other. Expand
Resolution of cutaneous inflammation after local elimination of macrophages
TLDR
An immunotoxin, composed of an antibody directed against the high-affinity IgG receptor CD64 and Ricin-A, was constructed with the aim of resolving chronic inflammation through elimination of activated macrophages, and proved very efficient in inducing apoptosis in activated Macrophages. Expand
Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH).
TLDR
The role of ERCC3 and probably the entire BTF2 complex in transcription in vivo which was hitherto only demonstrated in vitro is established and strongly suggests that transcription itself is a critical component for maintenance of chromatin structure. Expand
Sensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte‐derived microRNA‐122
TLDR
It is confirmed that liver injury is associated with high levels of hepatocyte‐derived microRNAs in circulation and demonstrated that in particular miR‐122 is a sensitive marker to distinguish chronic hepatitis C patients from healthy controls. Expand
Serum hepatitis B virus RNA predicts response to peginterferon treatment in HBeAg‐positive chronic hepatitis B
TLDR
It is concluded that early on‐treatment HBV RNA level may be used to predict nonresponse to peginterferon treatment, and declines profoundly during PEG‐IFN treatment. Expand
A Randomized Trial of Peginterferon α-2a With or Without Ribavirin for HBeAg-Negative Chronic Hepatitis B
TLDR
Treatment with peginterferon α-2a resulted in a limited sustained response rate in HBeAg-negative chronic hepatitis B patients, and combination therapy was well tolerated, although it was associated with a higher risk of anemia and neutropenia. Expand
Pharmacogenetics of thiopurine therapy in paediatric IBD patients
TLDR
The occurrence and type of adverse events to azathioprine may be related to thiopurine S‐methyltransferase (TPMT) enzyme activity and to inosine triphophate pyrophosphatase (ITPase) deficiency. Expand
Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi‐ethnic European city
TLDR
It is shown that immigrants from developing countries with high H. pylori prevalence have settled in Western urban areas and may help in realizing a more selective approach to assess H. pylori‐related diseases in a migrant community. Expand
The human Fc receptor for IgA (FcαRI, CD89) on transgenic peritoneal macrophages triggers phagocytosis and tumor cell lysis
TLDR
The transgenic mouse model presented in this study will help to define the precise conditions under which Fc alpha RI is expressed on macrophages, and represent a useful tool to study Fcalpha RI function in immune defense. Expand
Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18)
TLDR
Remarkably, the capacity to lyse tumor targets was ablated in hFcRI transgenic/ CR3−/− mice, although binding of neutrophils to tumor cells was intact, which shows a previously unrecognized importance of CR3 for hF cRI-mediated antibody-dependent cellular cytotoxicity (ADCC). Expand
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