A. J. Sweetman

Publications43
h-index10
Citations383
Highly Influential Citations10
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Input-output balance of PCBs in a long-term study of lactating dairy cattle.
A PCB input−output balance study was performed on five cows in which they were fed a natural background contaminated diet and kept under typical U.K. winter husbandry conditions for 15 weeks.… Expand
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ANTAGONISM OF ADENOSINE 5′‐TRIPHOSPHATE‐INDUCED RELAXATION BY 2‐2′‐PYRIDYLISATOGEN IN THE TAENIA OF GUINEA‐PIG CAECUM
1 2‐2′Pyridylisatogen tosylate (PIT) (>2.5 μM) relaxed the guinea‐pig isolated taenia caeci by an unknown mechanism. 2 With higher concentrations of PIT (>12.5 μM) subsequent applications of… Expand
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Studies on energy-linked reactions. Energy-linked transhydrogenase reaction in Escherichia coli.
1. Small particles from Escherichia coli catalyse an ATP-dependent reduction of NADP(+) by NADH. 2. The reaction was stimulated by Mg(2+) and only ATP and ITP could serve as energy donors. 3. Studies… Expand
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Action of the nonsteroidal anti-inflammatory agent, flufenamic acid, on calcium movements in isolated mitochondria.
The anti-inflammatory agent flufenamic acid was found to inhibit calcium uptake in isolated mitochondria at low concentrations (IC50 = 7.2 microM). Similar concentrations were required to promote the… Expand
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Palmitoyl carnitine: an endogenous promotor of calcium efflux from rat heart mitochondria.
The effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5-40 microM) PC was found to produce changes in… Expand
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PCBs in dairy cows : metabolism and body-burden.
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Realistic estimations of kinetic constants for the oxidation of naturally occurring monoamines by monoamine oxidase.
Abstract A sensitive and convenient assay for the determination of kinetic constants for MAO is described. Five naturally occurring substrates—tyramine, tryptamine, dopamine, 5-hydroxytryptamine, and… Expand
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The mechanism of inhibition of mitochondrial oxidative phosphorylation by the nonsteroidal anti-inflammatory agent diflunisal.
The anti-inflammatory agent diflunisal was found to induce a progressive loss of respiratory control in tightly coupled rat liver mitochondria, starting at low concentrations (3.3 microM). This loss… Expand
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Studies on energy-linked reactions. Energy-linked reduction of oxidized nicotinamide-adenine dinucleotide by succinate in Escherichia coli.
1. A method for the preparation of small particles from Escherichia coli is described. 2. These particles catalyse the ATP-driven reduction of NAD(+) by succinate. 3. ATP utilized/NADH produced… Expand
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ANTAGONISM OF THE INHIBITORY EFFECTS OF ADENOSINE 5′‐TRIPHOSPHATE ON THE ISOLATED TAENIA OF THE GUINEA‐PIG CAECUM: STRUCTURE‐ACTIVITY RELATIONSHIPS WITHIN A SERIES OF ISATOGEN DERIVATIVES
1 A series of eight isatogen derivatives was studied on isolated tissues taken from guinea‐pigs. The ability of the compounds to relax the taenia, to inhibit adenosine 5′‐diphosphate (ADP)‐stimulated… Expand
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