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Ionic mechanisms of action potential prolongation at low temperature in guinea‐pig ventricular myocytes.
TLDR
It was shown that simultaneous changes in these currents could reproduce approximately 75% of the action prolongation induced by low temperature, and a component of time‐independent current is also sensitive to the temperature. Expand
Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs
TLDR
Computer modeling studies support a role of this current in the dispersion of action potential duration across the ventricular wall in guinea pig ventricular myocytes. Expand
Sodium‐calcium exchange during the action potential in guinea‐pig ventricular cells.
TLDR
Slow inward tail currents attributable to electrogenic sodium‐calcium exchange can be recorded by imposing hyperpolarizing voltage clamp pulses during the normal action potential of isolated guinea‐pig ventricular cells and it was found that temperature has a large effect on the tail current. Expand
Background inward current in ventricular and atrial cells of the guinea-pig
TLDR
The permeability of theChannel to TMA was found to be pH dependent, suggesting that protonation of the channel is a factor determining permeation in addition to ionic size, and the channel selectivity behaves like an Eisenman group III/IV sequence. Expand
Mechanism of the use dependence of Ca2+ current in guinea‐pig myocytes.
TLDR
The facilitation of iCa is abolished by Ba2+ replacement of Ca2+ and by the beta‐adrenoceptor agonist isoprenaline, which suggests that the facilitation is mediated by Ca 2+ entry itself rather than membrane voltage. Expand
Use‐dependent reduction and facilitation of Ca2+ current in guinea‐pig myocytes.
TLDR
Variations in the level of Ca2+‐dependent inactivation of iCa can explain many features of the changes in iCa during stimulation after rest and this may reflect a lowered myoplasmicCa2+ level which allows facilitation of i Ca. Expand
Inward current related to contraction in guinea‐pig ventricular myocytes.
TLDR
The results are consistent with the hypothesis that the delayed inward current is activated by the intracellular calcium transient and carried by the sodium‐calcium exchange process and/or by calcium‐activated non‐specific channels. Expand
The arrhythmogenic transient inward current iTI and related contraction in isolated guinea‐pig ventricular myocytes.
TLDR
The voltage dependence of the Ca2+‐activated inward current in guinea‐pig ventricular myocytes leads us to favour electrogenic Na‐Ca exchange current as a major component of iTI, under experimental conditions. Expand
The effects of sodium substitution on currents determining the resting potential in guinea‐pig ventricular cells
TLDR
These experiments showed that the presence or absence of the inward rectifier current iK1 determines in which direction Na+ removal acts, which explains why removal of Na+ does not lead to hyperpolarization in ventricular cells as would be expected if changes in ib,Na were solely responsible. Expand
A new calcium current underlying the plateau of the cardiac action potential
A small and very slow inward calcium current has been identified in isolated single ventricular cells using TTX and Cd2+ to block the sodium and fast calcium currents. Activation requires about 300Expand
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