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Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries.
Analysis of locomotion is an important tool in the study of peripheral and central nervous system damage. Most locomotor scoring systems in rodents are based either upon open field locomotionExpand
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Injury-Induced Class 3 Semaphorin Expression in the Rat Spinal Cord
In this study we evaluate the expression of all members of the class 3 semaphorins and their receptor components following complete transection and contusion lesions of the adult rat spinal cord.Expand
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Collagen Containing Neurotrophin-3 (NT-3) Attracts Regrowing Injured Corticospinal Axons in the Adult Rat Spinal Cord and Promotes Partial Functional Recovery
During development, neurotrophic factors play an important role in the guidance and outgrowth of axons. Our working hypothesis is that neurotrophic factors involved in the development of axons of aExpand
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Functional recovery after central infusion of alpha-melanocyte-stimulating hormone in rats with spinal cord contusion injury.
Melanocortins, peptides related to alpha-melanocortin-stimulating hormone (alpha MSH) and adrenocorticotropic hormone (ACTH), are known to improve axonal regeneration following peripheral nerveExpand
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Locomotor recovery after spinal cord contusion injury in rats is improved by spontaneous exercise.
We have recently shown that enriched environment (EE) housing significantly enhances locomotor recovery following spinal cord contusion injury (SCI) in rats. As the type and intensity of locomotorExpand
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Effects of enriched housing on functional recovery after spinal cord contusive injury in the adult rat.
To date, most research performed in the area of spinal cord injury focuses on treatments designed to either prevent spreading lesion (secondary injury) or to enhance outgrowth of long descending andExpand
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New assessment techniques for evaluation of posttraumatic spinal cord function in the rat.
To evaluate new pharmacologic agents with potentially beneficial effects on posttraumatic spinal cord function, we used a modified weight drop (WD) technique to induce spinal cord injuries. TheseExpand
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Experimental spinal cord contusion injury: Comparison of different outcome parameters
Research on experimental spinal cord injuries recently underwent some major advances in lesion standardization and evaluation of locomotor recovery. Many laboratories now use the same lesionExpand
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Combined treatment with αMSH and methylprednisolone fails to improve functional recovery after spinal injury in the rat
To date, relatively little progress has been made in the treatment of spinal cord injury (SCI)-related neurological impairments. Until now, methylprednisolone (MP) is the only agent with clinicallyExpand
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Local application of collagen containing brain-derived neurotrophic factor decreases the loss of function after spinal cord injury in the adult rat
We studied the effect of local application of brain-derived neurotrophic factor (BDNF) on functional recovery after dorsal spinal cord transection in the adult rat. BDNF was applied at the site ofExpand
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