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Structure and efficiency in intramolecular and enzymic catalysis. Catalysis of amide hydrolysis by the carboxy-group of substituted maleamic acids
The efficiency of intramolecular catalysis of amide hydrolysis by the carboxy-group of a series of substituted N-methylmaleamic acids is remarkably sensitive to the pattern of substitution on theExpand
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Rational approaches to the design of cationic gemini surfactants for gene delivery.
We report a new class of amphiphilic gemini surfactants as vehicles for gene delivery into cells, and the beginnings of a systematic structure-activity study. Preliminary results suggest thatExpand
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Estimating pKa values for pentaoxyphosphoranes.
pKa values are estimated independently, by two entirely different methods, for the ionizations of the apical and equatorial OH groups of two representative hydroxyphosphoranes. A bond length-pKaExpand
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Chapter 2 Hydrolysis and Formation of Esters of Organic Acids
Publisher Summary The hydrolysis and formation of esters have been extensively studied than any other chemical reaction. This chapter brings together in one place a representative selection of theExpand
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The reactivity of phosphate esters. Reactions of diesters with nucleophiles
The reactions of a wide range of nucleophiles with a series of aryl methyl phosphate ester anions involve concerted nucleophilic displacement at phosphorus. The attack of neutral nucleophiles isExpand
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Off-the-shelf proteins that rival tailor-made antibodies as catalysts
MIMICKING the efficiency of enzyme catalysis is a daunting challenge. An enzyme selectively binds and stabilizes the transition state(s) for a particular reaction1,2. Artificial host systems can bindExpand
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Linear relationship between bond length and reactivity
The two C–O bond lengths of the acetal group in a series of compounds derived from 2-phenoxytetrahydropyran vary with the aryloxy leaving group, and are linearly related to the free energy ofExpand
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