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Structure-specificity of the genotoxicity of some naturally occurring alkenylbenzenes determined by the unscheduled DNA synthesis assay in rat hepatocytes.
Induction of unscheduled DNA synthesis in rat and hamster hepatocytes by cooked food mutagens.
Effect of dietary fibre on the mutagenicity and distribution of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ).
In Vitro and In Vivo Studies of Mutagens Found in Cooked Food.
- A. J. Howes
- Biology, Chemistry
Five heterocyclic aromatic amines, formed during the cooking of proteinaceous foods, were found to be genotoxic in an in vitro assay for unscheduled DNA synthesis (UDS), in rat and hamster hepatocytes, and MelQ showed the most potent response.
Roles of dietary fat and fibre in the disposition and metabolism of carcinogens associated with foods.
- W. E. Brennan-Craddock, A. J. Howes, T. Coutts, I. Rowland, A. Alldrick
- BiologyFood additives and contaminants
The abilities of dietary fibre (wheat bran) or fat (olive oil) to modify the genotoxicity of radiolabelled MeIQ were evaluated in mice using in vivo and in vitro bacterial mutation assays. Bran…
Nutritional modulation of xenobiotic metabolism.
Comparative studies on the metabolism of food additives : case examples in the safety evaluation of the allylbenzene natural flavors
Article de synthese sur le potentiel cancereux des additifs exhausteurs de saveur d'origine naturelle comme les allybenzenes. Etude cinetique et metabolique chez les rats et les souris des effets de…
The toxicological significance of xenobiotic metabolism.
These and similar data illustrate the usefulness of metabolic information in the specific context of the safety assessment of natural food flavours (JECFA 1987) by aiding the interpretation of toxicity tests and aiding the design of more relevant tests.