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- Publications
- Influence
β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma
- E. Pasquier, J. Street, +7 authors M. Kavallaris
- Medicine
- British Journal of Cancer
- 21 May 2013
Background:The use of β-blockers for the management of hypertension has been recently associated with significant clinical benefits in cancer patients. Herein, we investigated whether β-blockers… Expand
Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models
- Tammy Hennika, Guo Hu, +9 authors O. Becher
- Medicine
- PloS one
- 4 January 2017
Background Diffuse intrinsic pontine glioma (DIPG), or high-grade brainstem glioma (BSG), is one of the major causes of brain tumor-related deaths in children. Its prognosis has remained poor despite… Expand
Single nucleotide polymorphisms in the human reduced folate carrier: Characterization of a high-frequency G/A variant at position 80 and transport properties of the His27 and Arg27 carriers
- J. Whetstine, A. J. Gifford, +7 authors L. Matherly
- Biology
- 1 November 2001
The presence of sequence variants in the human reduced folate carrier ( hRFC ) was assessed in leukemia blasts from children with acute lymphoblastic leukemia (ALL) and in normal peripheral blood… Expand
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Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma
- Daniel R. Carter, J. Murray, +36 authors G. Marshall
- Biology, Medicine
- Science Translational Medicine
- 4 November 2015
Histone chaperone FACT acts in a positive feedback loop with MYCN and is a therapeutic target in neuroblastoma. Uncovering the FACTs in neuroblastoma Neuroblastoma is a common pediatric cancer of the… Expand
P‐glycoprotein‐mediated methotrexate resistance in CCRF‐CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene
- A. J. Gifford, M. Kavallaris, +4 authors M. Norris
- Biology, Medicine
- International journal of cancer
- 5 October 1998
We have previously described a series of methotrexate (MTX)‐selected CCRF‐CEM sublines (CEM/MTX R1–3) displaying increased resistance to drugs associated with the multidrug resistance phenotype and… Expand
Antenatal gastrointestinal anomalies in neonates subsequently found to have alveolar capillary dysplasia
- Dimple Goel, J. Oei, +5 authors C. Loo
- Medicine
- Clinical case reports
- 13 March 2017
Alveolar capillary dysplasia (ACD) is a rare condition with variable presentation and clinical course. Clinicians should consider this diagnosis in neonates presenting with nonlethal congenital… Expand
A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
- A. Krivtsov, Kathryn A Evans, +25 authors S. Armstrong
- Biology, Medicine
- Cancer cell
- 9 December 2019
Inhibition of the Menin (MEN1) and MLL (MLL1, KMT2A) interaction is a potential therapeutic strategy for MLL-rearranged (MLL-r) leukemia. Structure-based design yielded the potent, highly selective,… Expand
Intrapancreatic splenunculus.
- G. Meyer-Rochow, A. J. Gifford, J. Samra, M. Sywak
- Medicine
- American journal of surgery
- 2007
Intrapancreatic accessory spleens are uncommon, however, the recognition and appropriate confirmatory diagnostic imaging of an intrapancreatic splenunculus is important to avoid an unnecessary… Expand
Remote frozen section examination of breast sentinel lymph nodes by telepathology
- A. J. Gifford, A. Colebatch, +5 authors A. Gill
- Medicine
- ANZ journal of surgery
- 1 November 2012
Intraoperative sentinel lymph node (SLN) examination during breast cancer surgery guides the need for immediate axillary clearance. This may be difficult to implement when surgery is performed… Expand
Targeted Doxorubicin-Loaded Bacterially Derived Nano-Cells for the Treatment of Neuroblastoma
- S. M. Sagnella, Jennifer Trieu, +8 authors M. Kavallaris
- Medicine
- Molecular Cancer Therapeutics
- 28 February 2018
Advanced stage neuroblastoma is an aggressive disease with limited treatment options for patients with drug-resistant tumors. Targeted delivery of chemotherapy for pediatric cancers offers promise to… Expand