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Caffeine enhances acetylcholine release in the hippocampus in vivo by a selective interaction with adenosine A1 receptors.
It is demonstrated that acetylcholine release in the hippocampus is under tonic inhibitory control of the endogenous neuromodulator adenosine, and that orally administered caffeine enhances action potential-dependent vesicular acetyl choline release by antagonism of local A1 receptors.
Preincubation with Creatine Enhances Levels of Creatine Phosphate and Prevents Anoxic Damage in Rat Hippocampal Slices
Results indicate that energy status is a major factor controlling anoxic damage in the rat hippocampal slice and incubation with a combination of both creatine and the noncompetitive NMDA antagonist MK‐801 provided complete protection.
Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL.
The results demonstrate that BIII 890 CL is a potent, selective, and highly use-dependent Na(+) channel blocker that protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents.
Hippocampal noradrenaline release in awake, freely moving rats is regulated by alpha-2 adrenoceptors but not by adenosine receptors.
  • A. J. Carter
  • Biology
    The Journal of pharmacology and experimental…
  • 1 May 1997
Results indicate that base-line and K(+)-stimulated extracellular levels of noradrenaline in the hippocampus of awake, freely moving rats are regulated by alpha-2 adrenoceptors and not by adenosine receptors.