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Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology
TLDR
The aim of this article is to outline the rationale for, and the expectations of, the BJP with respect to work published in the Journal that includes immunoblotting or immunohistochemical data and to reduce potential misinterpretations and to maximise the communication and transparency of essential information. Expand
ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020
TLDR
The BJP has been and remains an active advocate of the ARRIVE guidelines and the Editor in Chief of the BJP is a member of the new team that was assembled, which triggered a reappraisal of the guidelines led by the NC3Rs who, in 2018, established a new, international Working Group to review and update the ARrIVE guidelines. Expand
Experimental design and analysis and their reporting: new guidance for publication in BJP
TLDR
This Editorial is part of a series of editorials based on research published in The Lancet Onlinelibrary.wiley.com/doi/10.1111/bph.13112/abstract. Expand
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
TLDR
Cannabidiol and Delta(9)-tetrahydrocannabivarin, a novel CB(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity are given special emphasis. Expand
Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers
TLDR
The guidelines have been simplified for ease of understanding by authors, to make it more straightforward for peer reviewers to check compliance and to facilitate the curation of the journal's efforts to improve standards. Expand
Flavonoids: old and new aspects of a class of natural therapeutic drugs.
TLDR
This review summarizes available data on these beneficial effects of flavonoids and suggests that the compounds may possess significant antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and even antitumor activities. Expand
A multistage tuberculosis vaccine that confers efficient protection before and after exposure
TLDR
A multistage vaccination strategy in which the early antigens Ag85B and 6-kDa early secretory antigenic target (ESAT-6) are combined with the latency-associated protein Rv2660c (H56 vaccine), which confers protective immunity characterized by a more efficient containment of late-stage infection. Expand
Cannabinoids and the gut: new developments and emerging concepts.
TLDR
Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric infections and inflammatory conditions to disorders of motility, emesis and abdominal pain, with recent data on genetic mutations in the endocannabinoid system in GI disease highlighted. Expand
Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High‐fat Diet
TLDR
In mice, endocannabinoids modulate insulin release from pancreatic β‐cells and adipokine expression in adipocytes through cannabinoid receptors through cannabinoids receptors, and these alterations are elevated during hyperglycemia and obesity. Expand
Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
TLDR
It is concluded that inflammation of the gut increases the potency of cannabinoid agonists possibly by ‘up‐regulating’ CB1 receptor expression; in addition, endocannabinoids, whose turnover is increased in inflamed gut, might tonically inhibit intestinal motility. Expand
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