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Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3.
GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activity of GTPases. We recently reported the identification of a new GDI for the Rho-related GTPases named RhoGDIgamma. This… Expand
Expression of the cytochrome b-URF6-URF5 region of the mouse mitochondrial genome.
- K. S. Bhat, N. K. Bhat, G. Kulkarni, A. Iyengar, N. Avadhani
- Chemistry, Medicine
- 8 October 1985
The nature of RNA coded by the only light-strand (L-strand) open-reading frame unidentified reading frame 6 (URF6) was studied by using a variety of single- and double-strand DNA subclones derived… Expand
Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead
Nerve agents (NAs) are extremely neurotoxic synthetic organophosphate (OP) compounds exploited as weapons of mass destruction in terrorist attacks and chemical warfare. Considering the current world… Expand
Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192
- Geetika Aggarwal, Rameshwar Prajapati, +4 authors A. Pande
- Chemistry, Medicine
- PloS one
- 1 February 2016
Human paraoxonase 1 (h-PON1) is a serum enzyme that can hydrolyze a variety of substrates. The enzyme exhibits anti-inflammatory, anti-oxidative, anti-atherogenic, anti-diabetic, anti-microbial and… Expand
Development of Neutral Liposome Plasmid DNA Complexes for Gene Transfer: Non-Viral Gene Delivery Systems
Is human Paraoxonase 1 the saviour against the persistent threat of Organophosphorus nerve agents?
Nerve agents have been used extensively in chemical warfare in the past. However, recent use of Novichok agents have reignited the debate on the threat posed by Organophosphorus Nerve Agents (OPNAs).… Expand
RECOMBINANT HUMAN INTERFERON-BETA: CURRENT PERSPECTIVES
Recombinant human interferon-beta (rhIFN-β) is a drug of choice for the treatment of multiple sclerosis and is also a potential candidate for the treatment of several other diseases in humans.… Expand
Protein Chimerization: A New Frontier for Engineering Protein Therapeutics with Improved Pharmacokinetics
- A. Iyengar, Shreya Gupta, S. Jawalekar, A. Pande
- The Journal of Pharmacology and Experimental…
- 1 September 2019
With the advancement of medicine, the utility of protein therapeutics is increasing exponentially. However, a significant number of protein therapeutics suffer from grave limitations, which include… Expand