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Cystometric findings in mice lacking muscarinic M2 or M3 receptors.
TLDR
Functional impairments found in M3 KO mice were milder than those elicited by acute blockade of muscarinic receptors by atropine in WT mice, suggesting that noncholinergic mechanisms can compensate for a chronic loss of M3 receptors.
Effects of teriparatide in Japanese and non-Japanese populations: bridging findings on pharmacokinetics and efficacy
TLDR
Analysis of data from single teriparatide doses in healthy Japanese and Caucasian postmenopausal women and from studies of randomized, placebo-controlled, once-daily treatment in Japanese subjects with osteoporosis show that terIParatide clinical data met ICH E-5 criteria for bridging, and findings from foreign trials such as the FPT can be extrapolated to Japanese subjects treated with teripatinide 20 μg/day.
Changes in parathyroid hormone receptor binding affinity during egg laying: Implications for calcium homeostasis in chicken
TLDR
The results suggest that the PTH receptor binding in the calvaria and the kidney is affected by ovarian steroid hormones and may play a role in maintaining the calcium homeostasis in the egg‐laying hen.
Lund University Hospital IN VIVO AND IN VITRO FUNCTIONAL CHANGES OF THE URINARY BLADDER IN MICE LACKING MUSCARINIC M 2 OR M 3 RECEPTORS
Aims of Study Detrusor muscle function has been studied previously in vitro in both M3 and M2 muscarinic receptor knockout mice, and important gender differences have been suggested [1,2]. However,