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Identification of Receptor and Heparin Binding Sites in Fibroblast Growth Factor 4 by Structure-Based Mutagenesis
TLDR
FGF4, like FGF2, but unlike FGF1, engages the βC′-βE loop in D3 and thus can differentiate between the IIIc and IIIb splice isoforms of FGFRs for binding, and it is shown that FGF4 needs to interact with both the 2-O and 6-O-sulfates in heparin to exert its optimal biological activity.
Activation of fgf4 gene expression in the myotomes is regulated by myogenic bHLH factors and by sonic hedgehog.
TLDR
It is shown that expression of an Fgf4-lacZ transgene in Shh-/- embryos is suppressed not only in the epaxial but also in the hypaxial myotomes, while it is maintained in the AER, suggesting that Shh mediates FgF4 activation in the myotome through mechanisms independent of its role in the activation of myogenic factors.
Effects of development on acetoacetyl-CoA synthetase biosynthesis in rat liver.
TLDR
Results indicate that changes in this enzyme activity and content during the developmental process might influence the rate of ketone body utilization for the formation of physiologically important lipidic substances in rat liver.
Synthesis of reversed magainin 2 analogs enhanced antibacterial activity.
TLDR
The synthesized reversed analogs, the A87-ISM, that is, the reverse of MSI-78A enhanced the amphiphilicity and the alpha-helical tendency of magainin 2, showed not only almost the same antibacterial activity against the bacteria as MSI- 78A, but also stronger activity than other magain in 2 analogs.
Antibacterial activity of two alkylamines integrated an indane scaffold: mimicry of a complementary unit on magainin 2.
TLDR
Two indanes showed stronger antibacterial activity against two strains of Helicobacter pylori than either pC9a or magainin 2 related peptides, indicating that an indane scaffold, used as a template to mimic a part of the alpha-helical structure of magain in 2, can accelerate the killing rate.
Tunicamycin in combination with retinoic acid synergistically inhibits cell growth while decreasing palmitoylation and enhancing retinoylation of proteins in the human breast cancer cell line MCF-7.
TLDR
The results suggest that increased retinoylation and decreased glycosylation and palmitoylation may play a role in the synergistic inhibition of cell growth by combinations of TM and RA in MCF-7 cells.
On the antibacterial activity of normal and reversed magainin 2 analogs against Helicobacter pylori.
TLDR
The testing of antibacterial activities of normal and reversed magainin 2 analogs against two strains of Helicobacter pylori indicates that the net charge of the cell surface in H.pylori may be more negative than that of E. coli, though both strains belong to the same genus.
Antibacterial activity of (+/-) 6-benzyl-1-(3-carboxypropyl) indane; a possible way to identify leading novel anti-H. pylori agents.
TLDR
The possibility that PM2c may be more useful than PM2 either alone or in combination with well-known therapeutic agents for the treatment of H. pylori infection is indicated.
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