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Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.
TLDR
A new ligand-dependent recombinase, Cre-ER(T2), was recently characterized, which was approximately 4-fold more efficiently induced by OHT than Cre- ER(T) in cultured cells, and a dose-response study showed that Cre-Er(T 2) was approximately 10- fold more sensitive to OHT induction thanCre-ER (T).
Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis
TLDR
It is shown that RXRα has key roles in hair cycling, probably through RXR/VDR heterodimers, and in epidermal keratinocyte proliferation and differentiation, and by developing an efficient technique to create spatio-temporally controlled somatic mutations in the mouse.
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.
TLDR
Distinct RXRalpha-mediated molecular events appear to be involved, in keratinocytes, in cell-aut autonomous suppression of epidermal tumorigenesis and malignant progression, and in non-cell-autonomous suppression of nevi formation and progression.
Endothelin‐1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet‐induced melanocyte homeostasis
TLDR
An essential role of EDN1 in epidermal keratinocytes to mediate UV‐induced melanocyte homeostasis in vivo is established.
Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin
TLDR
It is shown that cell-specific targeted somatic mutations can be created at various times during the development of mouse embryos cell- specifically expressing the tamoxifen-activatable Cre-ERT2 recombinase and selectively ablated Brg1 in keratinocytes of the forming mouse epidermis.
Targeted Somatic Mutagenesis in Mouse Epidermis
TLDR
It is shown that LoxP flanked (floxed) DNA segments were efficiently excised in epidermal keratinocytes of K14-Cre transgenic mice, and Tamoxifen administration to adult K 14-Cre-ERT2 mice efficiently induced recombination in the basal keratinocyte, whereas no background recombination was detected in the absence of ligand treatment.
Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.
TLDR
The analysis of conditionally null mice suggests that CTIP2 functions as a top-level regulator of skin morphogenesis, in both cell and non-cell autonomous contexts to exert regulatory influence over multiple phases of skin development, including barrier establishment.
Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis
  • A. Indra
  • Medicine
    Expert review of proteomics
  • 1 August 2013
Atopic dermatitis (AD) is a common allergic inflammatory skin disease that affects 10–20% of infants, besides 3–5% of adults, and is often linked with family history of allergic disease [1]. It is ...
TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis.
TLDR
This study demonstrates for the first time a differential in vivo requirement for a mammalian TAF for the regulation of gene expression depending on the cellular environment and developmental stage of the cell.
Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans
TLDR
Skin lipidomics analysis could be a fast, reliable and noninvasive tool to characterize the skin lipid profile and to monitor the progression of inflammatory skin diseases such as AD.
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