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Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects.
A sandwich ELISA system enabling detection of circulating serum salphaKl levels and relationship to indices of renal function, mineral metabolism, age and sex in healthy subjects was established and correlated negatively with age and Ca, and positively with Pi.
Secreted Klotho protein in sera and CSF: implication for post‐translational cleavage in release of Klotho protein from cell membrane
Results delineate post‐translation processing of Klotho and possible regulatory mechanisms for secretion ofklotho in vivo and suggest the secreted as well as the membrane‐bound Klotha proteins were suggested to form oligomerized complex.
α-Klotho as a Regulator of Calcium Homeostasis
Fundamental roles of α-Kl in the regulation of calcium metabolism are revealed and the increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney.
Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor.
The atomic structures of CHMO are presented from an environmental Rhodococcus strain bound with FAD and NADP(+) in two distinct states, to resolutions of 2.3 and 2.2 A. Taken together, these structures provide mechanistic insights into CHMO-catalyzed Baeyer-Villiger oxidation.
Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress
A new gene, termed klotho, is associated with the suppression of several aging phenotypes. Because high expression of klotho gene was detected in the brain, it would be plausible that klotho gene is
A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism
It is suggested that the elevated α-Klotho level mimics aspects of the normal response to hyperphosphatemia and implicate α-Lotho in the selective regulation of phosphate levels and in the regulation of parathyroid mass and function; they have implications for the pathogenesis and treatment of renal osteodystrophy in patients with kidney failure.
Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation*
Results indicate that the NF-κB activation resulting from OX40 stimulation is mediated by both TRAF2 and TRAF5, and is likely to be negatively modulated by TRAF3.
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice.
Results indicate that hyperphosphatemia in klotho mice is due to dysregulation of expression and trafficking of the renal type IIa/IIc transporters rather than to intestinal P(i) uptake.
The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells
Results indicate that the OX40/gp34 system directly mediates adhesion of activated T cells or Ox40+-transformed T cells to vascular endothelial cells.
Relevant use of Klotho in FGF19 subfamily signaling system in vivo
Findings suggest the existence of Klotho-independent FGF21 signaling pathway(s) where undefined cofactors are involved, and one-to-one functional interactions such as α-Klotho/FGF23, β-KLotho /FGF15 (humanFGF19), and undefined cofactor/F GF21 would result in tissue-specific signal transduction of the FGF19 subfamily.