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The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.
- K. Kabashima, T. Saji, +9 authors S. Narumiya
- The Journal of clinical investigation
- 1 April 2002
We used mice deficient in each of the eight types and subtypes of prostanoid receptors and examined the roles of prostanoids in dextran sodium sulfate-induced (DSS-induced) colitis. Among the… Expand
The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs.
PGE2 functions as a potent stimulator of bone resorption. The action of PGE2 is thought to be mediated by some PGE receptor subtypes present in osteoblastic cells. In this study, we examined the… Expand
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
Prostanoids are a group of bioactive lipids working as local mediators and include D, E, F and I types of prostaglandins (PGs) and thromboxanes. Prostacyclin (PGI2) acts on platelets and blood… Expand
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
Fever, a hallmark of disease, is elicited by exogenous pyrogens, that is, cellular components, such as lipopolysaccharide (LPS), of infectious organisms, as well as by non-infectious inflammatory… Expand
Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity
PEPTIDE hormones, neurotransmitters, and autacoids activate a family of seven-transmembrane-domain receptors1. Each of these receptors specifically couples to one of several G proteins, Gs, Gi, Go… Expand
Molecular mechanisms of diverse actions of prostanoid receptors.
This review summarizes recent advances in the molecular characterization of prostanoid receptors. Prostanoids exert versatile actions in diverse tissues and cells through specific cell surface… Expand
A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained Ca2+ Influx and IL-2 Production in T Lymphocytes
In nonexcitable cells, Ca2+ entry is mediated predominantly through the store depletion-dependent Ca2+ channels called store-operated Ca2+ (SOC) or Ca2+ release-activated Ca2+ channels. YM-58483, a… Expand
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.
- A. Honda, Y. Sugimoto, +5 authors A. Ichikawa
- Biology, Medicine
- The Journal of biological chemistry
- 15 April 1993
A functional cDNA clone encoding mouse EP2 subtype of prostaglandin (PG) E receptor was isolated from a mouse cDNA library by cross-hybridization with the mouse EP3 subtype PGE receptor cDNA. The… Expand
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2).
- H. Hizaki, E. Segi, +9 authors A. Ichikawa
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 31 August 1999
Female mice lacking the gene encoding the prostaglandin (PG) E(2) receptor subtype EP(2) (EP(2)(-/-)) become pregnant and deliver their pups at term, but with a much reduced litter size. A decrease… Expand
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors.
Previous studies have disagreed about whether prostaglandin EP1 or EP3 receptors are critical for producing febrile responses. We therefore injected lipopolysaccharide (LPS) at a variety doses (1… Expand